NCT05103384Completed
Utilizing Neural Signatures and Virtual Reality to Advance DBS Programming
Source: ClinicalTrials.gov · Last updated 4 Nov 2025
Brief summary (registry, in English)
The project uses virtual reality technology to recreate situations that cause freezing of gait in individuals with Parkinson's disease. Individuals who underwent deep brain stimulator (DBS) surgery for Parkinson's disease will walk through a virtual reality environment while brain signals are recorded from the DBS device. The goal is to better understand what occurs in the brain during freezing of gait.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 15 (actual)
- First submitted
- 30 Sept 2021
- Start date
- 22 Jul 2022
- Primary completion date
- 24 Jun 2024
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Parkinson disease
- NCT number
- NCT05103384
What you commit to
- Study type: Observational
- Participants enrolled: 15
- From 22 Jul 2022 to the primary completion date, 24 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neurological disease other than PD, such as stroke or multiple sclerosis
- Musculoskeletal impairment that affects one's ability to ambulate
- Presence of active and untreated psychiatric symptoms meeting Diagnostic and Statistical Manual of Mental Disorders-4th Edition (DSM-IV) criteria for Axis-I disorder. Depression and anxiety are very common in patients with Parkinson's disease and are often mitigated as part of routine care. Depression and anxiety will not preclude study participation
- Cognitive impairment meeting Diagnostic and Statistical Manual of Mental Disorders-4th Edition (DSM-IV) criteria for dementia on formal neuropsychological evaluation
- Hearing or visual impairment precluding VR use
Other
- Current alcohol or substance abuse
- Lack of fluency in English which may invalidate certain tests
Who the study is looking for
- Clinical diagnosis of idiopathic PD
- Undergoing scheduled surgery for bilateral STN-DBS at a Cleveland Clinic facility or previously undergone STN-DBS surgery with the Medtronic Percept BrainSense DBS system
- Self-reported response of one or greater on question #3 of the Freezing of Gait Questionnaire (FOG-Q)
- Ability to walk independently for a minimum of 10 minutes
- Ability to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.