NCT05106036Recruiting
Preventing Cognitive Decline by Reducing BP Target Trial
Source: ClinicalTrials.gov · Last updated 3 Dec 2025
Brief summary (registry, in English)
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 4000 (estimated)
- First submitted
- 27 Sept 2021
- Start date
- 11 Jul 2022
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- High blood pressure
- NCT number
- NCT05106036
What you commit to
- Study type: Interventional
- Planned participants: 4000
- From 11 Jul 2022 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chemotherapy
Other illness
- Presence of dementia, Alzheimer's disease, or significant neurological disease
- Major and unstable heart disease (e.g., acute heart failure (systolic or diastolic), acute on chronic heart failure (systolic or diastolic), acute coronary syndrome or cardiac arrest, liver or renal transplantation
- Chronic kidney disease stage 5 or ESKD
- Any conditions judged by the medical providers to contraindicate participation due to risk to patient safety or lack of adherence
Age
- Under 70 years of age
Other
- Blood pressure consistently \<130/80 mmHg
- Inability to write or speak English or Spanish
- Expected life expectancy under a year
Who the study is looking for
- High BP defined as at least 1 BP readings of SBP \>= 130 or DBP \>=80 during the 24 months prior to enrollment
- Clinic visit with primary care provider within the last 24 months
- Ability to write and speak English or Spanish
- 70 years of age or older
- Ability to understand and willingness to provide informed consent
- Owns a smartphone
Age in the registry: 70 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.