NCT05114798Active, not recruiting
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
Effects of Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers Among Adults With Obesity
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
Approximately 42% of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically needed. This research will demonstrate that time-restricted eating, a type of intermittent fasting, is an effective therapy to help obese individuals reduce and control their body weight and prevent the development of colorectal cancer.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 194 (actual)
- First submitted
- 29 Sept 2021
- Start date
- 17 May 2022
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Obesity, Colorectal cancer
- NCT number
- NCT05114798
What you commit to
- Study type: Interventional
- Participants enrolled: 194
- From 17 May 2022 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Abuse alcohol (\> 50 grams/day), illicit drugs (other than self-reported marijuana use), or use combustible tobacco;
- Are not weight stable for 3 months prior to the study (weight gain or loss \> 4 kg);
- Are taking drugs that influence study outcomes (weight loss medications);
- Are taking anticoagulant medications or medications with endoscopic risk
- Are taking antivirals or immunosuppressant medications
Other illness
- Have a history of renal disease, autoimmune disorders, immunodeficiency, malabsorptive disorder, significant gastrointestinal and hepatic disease, surgical change in gastrointestinal anatomy, severe ischemic heart disease, severe pulmonary disease, severe mental health disorder, eating disorder, or bariatric surgery;
- Have a history of cancer treatment within the past 12 months, CRC, genetic predisposition to CRC (e.g., Lynch syndrome);
Lab values
- Have controlled type 2 diabetes or undiagnosed uncontrolled diabetes based on hemoglobin A1c (HbA1c) \> 9.0%;
Other
- Have a baseline body weight \> 450 lbs (weight limitation of the DXA);
- Are on a weight loss diet or actively involved in a formal weight loss program (e.g., Weight Watchers);
- Are unable to keep a food diary for 7 consecutive days during screening;
- Are night shift workers;
- Are pregnant or trying to get pregnant;
- Are non-English speaking
- Don't have regular access to an email address and computer/smartphone/tablet
- Are currently following a diet that requires fasting on a weekly basis
- Currently eat for less than 10 hours of the day (determined by asking participants what time they start and stop eating on a usual day)
Who the study is looking for
- 45-70 years old,
- BMI 30-49.99 kg/m2
- Are up to date with CRC screening.
Age in the registry: 45 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Illinois at Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.