NCT05115682Completed
Circadian Rhythm and Metabolic Effects of Exercise
Time of Day Specific Glycaemic and Metabolic Response to High-Intensity Interval Training
Source: ClinicalTrials.gov · Last updated 21 Feb 2025
Brief summary (registry, in English)
Physical exercise is efficacious in controlling blood glucose levels in individuals with Type 2 diabetes. An individual's exercise capacity and ability to utilize glucose as an energy source oscillates throughout the day. Hence, the beneficial effects of exercise on blood glucose levels may depend on the time of day when the exercise bout is performed. However, the time of day in which the most beneficial adaptations to exercise can be achieved remains unknown. This project aims to answer the following questions: Does time of day impact the beneficial effects of exercise on blood glucose? If so, when can the most beneficial effects of exercise be achieved? Which metabolic mechanisms links time of day, exercise and blood glucose control? To address these questions, individuals with or without Type 2 diabetes will perform an exercise session at two different times (09:00 and 16:00), and continuous glucose monitoring will be used to assess the effects of exercise on blood glucose. We will determine the specific metabolic processes which promote the most beneficial blood glucose response. To achieve this, we will measure which metabolic substrates (carbohydrates, lipids and proteins) are used and which metabolites produced in blood, skeletal muscle and adipose tissue in response to exercise at different times of the day.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 48 (actual)
- First submitted
- 19 Oct 2021
- Start date
- 10 Nov 2021
- Primary completion date
- 25 Jun 2024
- Lead sponsor
- Karolinska Institutet
- Diseases
- Type 2 diabetes
- NCT number
- NCT05115682
What you commit to
- Study type: Interventional
- Participants enrolled: 48
- From 10 Nov 2021 to the primary completion date, 25 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications: Insulin
- Current nicotine user (cigarettes, snus, nicotine gum) or past nicotine users less than 6 months before inclusion in the study
Other illness
- Pre-existing cardiovascular condition (Angina pectoris, Cardiac arrhythmia, Cardiac infarction, Coronary stent / angiography, Cerebrovascular insult, Hypertension \[\> 160 mmHg systolic, or \> 95 mmHg diastolic\])
- Pre-existing blood-borne disease (HIV, Hepatitis C, MRSA)
- Pre-existing systemic or localized rheumatic illness
- Malignant Disease
- Pre-existing psychiatric disorder
- Another pre-existing systemic disease
Who the study is looking for
- Body Mass Index (BMI): 23 - 33 kg/m2
- Participants diagnosed with Type 2 Diabetes (insulin independent) or participants without Type 2 Diabetes (based on normal HbA1c and fasting glucose levels).
- Ability to provide informed consent
- Ability to complete the exercise regiment
Age in the registry: 45 years to 68 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska Institutet Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.