NCT05119075Completed
Psychological Effects of Levodopa in Parkinson's Disease
Unravelling the Impact of Levodopa on Dysfunctional Brain Networks in Parkinson's Disease With Neuropsychiatric Fluctuations
Source: ClinicalTrials.gov · Last updated 13 Apr 2025
Brief summary (registry, in English)
The investigators aim is to study neuropsychiatric symptoms and underlying abnormalities in resting-state fMRI in patients with Parkinson's disease (PD) suffering from neuropsychiatric fluctuations, to enhance the understanding of the pathophysiological mechanisms underlying neuropsychiatric symptoms.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 23 (actual)
- First submitted
- 28 Sept 2021
- Start date
- Nov 2021
- Primary completion date
- Mar 2024
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- Diseases
- Parkinson disease
- NCT number
- NCT05119075
What you commit to
- Study type: Interventional
- Participants enrolled: 23
- From Nov 2021 to the primary completion date, Mar 2024
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Structural brain disease other than Parkinson's disease
Other
- Substance abuse and/or dependence (other than DRT)
- Ongoing depression with suicidal ideation
- Severe tremors/dyskinesia/ interfering with MRI performance
- Participating in a pharmacological study
- Inability to provide informed consent (legal guardianship)
- MRI contraindications
- Pregnancy
Who the study is looking for
- Adults above 18 years old
- Male or female
- Diagnosed with Parkinson's disease
- Able to understand instructions, neuropsychological tests and provide written informed consent
- Able to understand the locally used language of the experimental site and speak fluently
- Presence of neuropsychiatric fluctuations, defined as the sum ≥ 3 of items included in the Ardouin Scale of Behaviour in Parkinson's Disease (ASBPD) part 2
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Inselspital, Berne Coordinator of this site? Confirm its status | Bern | Switzerland | Unknown status |
| EPFL Institute of Bioengineering Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| University Hospital Geneva (HUG) Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| EPFL Campus Biotech Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.