NCT05121545Active, not recruiting
Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors
A Phase 1 Study of Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors (ProGRID)
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
This is a single arm, phase I study, evaluating the feasibility, toxicity, and degree of tumor response after novel proton pencil beam scanning (PBS GRID) treatment in patients with bulky tumors that are difficult to manage.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 4 Nov 2021
- Start date
- 6 Apr 2022
- Primary completion date
- 24 Sept 2024
- Lead sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- NCT number
- NCT05121545
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 6 Apr 2022 to the primary completion date, 24 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- For patients with prior RT that overlaps with Pro-GRID: Dicoms not available Pregnant women
Age
- Age \< 18
Other
- ECOG performance status 3-4
- Planned for definitive, curative management
- Tumor encasing critical structure, as defined by the treating MD.
Who the study is looking for
- Age \> 18
- Histologically or cytologically confirmed invasive cancer
- Bulky tumor \> 7 cm, determined clinically and/or radiographically, at the time of evaluation prior to enrollment
- Treated indicated for palliative intent
- Eastern Cooperative Oncology Group (ECOG) performance status \< 2
- Anticipated treatment deemed safe on pre-review by PI
- For patients with prior Radiation Therapy (RT): Dicoms must be available for dose fusion if overlap anticipated with GRID
- Willing and able to provide informed consent
- Discussion with medical oncology or surgical specialty
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sibley Memorial Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.