NCT05125237Completed
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene
Source: ClinicalTrials.gov · Last updated 6 Nov 2025
Brief summary (registry, in English)
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 155963 (actual)
- First submitted
- 8 Nov 2021
- Start date
- 1 Oct 2021
- Primary completion date
- 7 Jul 2023
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- High blood pressure
- NCT number
- NCT05125237
What you commit to
- Study type: Observational
- Participants enrolled: 155963
- From 1 Oct 2021 to the primary completion date, 7 Jul 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 1\. Prior history of dementia measured anytime prior to cohort entry date
- 2\. Prior use of amiloride or triamterene any time prior to cohort entry date
Who the study is looking for
- 1\. Aged \> 65 years on the index date
- 2\. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date
- 3\. At least two claims with hypertension diagnosis recorded in 365 days prior to cohort entry date
Criteria the registry did not label
- Please see https://docs.google.com/spreadsheets/d/1IdoLUI5-bz\_1D\_0IflZovJO9e1\_3kFLc\_JLEFM030No/edit?usp=sharing or Appendix A for full code and algorithm definitions.
- Medicare timeframe: 2008 to 2018 (end of data availability).
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.