NCT05125276Active, not recruitingPhase 4
LEGACY
Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients
Source: EU CTIS (euclinicaltrials.eu) · Last updated 19 Jun 2026
Brief summary (registry, in English)
This study will assess whether omitting aspirin reduces the rate of major or minor bleeding while remaining non-inferior to the current standard of care with regards to ischemic events in patients with non-ST segment elevation acute coronary syndrome.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 3090 (estimated)
- First submitted
- 10 Mar 2023
- Start date
- 13 May 2022
- Lead sponsor
- Amsterdam UMC
- Diseases
- Coronary artery disease
- NCT number
- NCT05125276
- EU CT number
- 2023-504360-42-00
- EudraCT number
- 2021-005550-28
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 3090
- 24 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent use of oral anticoagulants (e.g. because of atrial fibrillation)
- Planned surgical intervention within 12 months of PCI
- Participation in another trial with an investigational drug or device
Other illness
- Known allergy or contraindication for aspirin or all commercially available P2Y12-inhibitors (i.e. ticagrelor, prasugrel and clopidogrel)
Other
- Ongoing indication for DAPT at admission (e.g. due to recent PCI or ACS)
- Pregnant or breastfeeding women at time of enrolment
Who the study is looking for
- Clinical diagnosis of NSTE-ACS (i.e. NSTEMI or unstable angina)
- Successful PCI (according to the treating physician)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (24)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Onze Lieve Vrouw Ziekenhuis Coordinator of this site? Confirm its status | Aalst | Belgium | Active, not recruiting |
| Het Ziekenhuisnetwerk Antwerpen Coordinator of this site? Confirm its status | Antwerp | Belgium | Active, not recruiting |
| Imelda Coordinator of this site? Confirm its status | Bonheiden | Belgium | Active, not recruiting |
| UZ Brussel Coordinator of this site? Confirm its status | Jette | Belgium | Active, not recruiting |
| Chu Helora Coordinator of this site? Confirm its status | La Louvière | Belgium | Active, not recruiting |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Active, not recruiting |
| CHC MontLégia Coordinator of this site? Confirm its status | Liège | Belgium | Active, not recruiting |
| Noordwest Ziekenhuisgroep Stichting Coordinator of this site? Confirm its status | Alkmaar | Netherlands | Active, not recruiting |
| Stichting OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Active, not recruiting |
| Amsterdam UMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Active, not recruiting |
| Stichting Rijnstate Ziekenhuis Coordinator of this site? Confirm its status | Arnhem | Netherlands | Active, not recruiting |
| Stichting Treant Ziekenhuiszorg Coordinator of this site? Confirm its status | Emmen | Netherlands | Active, not recruiting |
| Stichting Zuyderland Medisch Centrum Coordinator of this site? Confirm its status | Heerlen | Netherlands | Active, not recruiting |
| Tergooiziekenhuizen Coordinator of this site? Confirm its status | Hilversum | Netherlands | Active, not recruiting |
| Medisch Centrum Leeuwarden B.V. Coordinator of this site? Confirm its status | Leeuwarden | Netherlands | Active, not recruiting |
| Leiden University Medical Center Coordinator of this site? Confirm its status | Leiden | Netherlands | Active, not recruiting |
| Maastricht University Coordinator of this site? Confirm its status | Maastricht | Netherlands | Active, not recruiting |
| St. Antonius Hospital Coordinator of this site? Confirm its status | Nieuwegein | Netherlands | Active, not recruiting |
| Stichting Radboud University Medical Center Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Active, not recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Active, not recruiting |
| Haga Hospital Coordinator of this site? Confirm its status | 's-Gravenhage | Netherlands | Active, not recruiting |
| Jeroen Bosch Ziekenhuis Coordinator of this site? Confirm its status | 's-Hertogenbosch | Netherlands | Active, not recruiting |
| Utrecht University Coordinator of this site? Confirm its status | Utrecht | Netherlands | Active, not recruiting |
| Isala Klinieken Stichting Coordinator of this site? Confirm its status | Zwolle | Netherlands | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.