NCT05136092Completed
A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors
Source: ClinicalTrials.gov · Last updated 6 Nov 2024
Brief summary (registry, in English)
This proposed study is designed to investigate the specific uptake of fructose by human colorectal tumors. In this study, subjects with colorectal cancer undergoing surgery will receive an oral sugar solution containing fructose or xylose prior to surgery. The tumor will then be resected, and a portion of the tissue will be used to measure the abundance of fructose and xylose. The study hypothesis is that the tumors will take up fructose sugar but not xylose sugar. A comparison of the sugar uptake between the tumor and normal tissues from the adjacent intestinal epithelium and smooth muscle and the liver will be conducted. This proposal will confirm that human colorectal cancer tumors can directly absorb dietary sugars, which has never been demonstrated.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 11 Nov 2021
- Start date
- 16 Feb 2022
- Primary completion date
- 27 Aug 2024
- Lead sponsor
- Weill Medical College of Cornell University
- Diseases
- Colorectal cancer
- NCT number
- NCT05136092
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 16 Feb 2022 to the primary completion date, 27 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients on steroid medications
Other illness
- Subjects with a history of uncontrolled diabetes mellitus (A1C \>7.0) Type I and Type 2, will be excluded to avoid potential confounders associated with the consumption of a large bolus of sugar (e.g., hyperglycemia and hyperinsulinemia)
- Inflammatory Bowel Disease (Ulcerative Colitis or Crohn's Disease)
- Patients with current infectious disease
Other
- Subjects who do not speak English
Who the study is looking for
- Subjects of 18 years of age or older, male, and female
- Subjects with a diagnosis of invasive non-hereditary colonic adenocarcinoma who will be undergoing standard of care (SOC) laparoscopic, robot-assisted, or open surgical resection
- The subject provides informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Weill Cornell Medicine Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.