NCT05138263Active, not recruiting
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2 (KBASE2)
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2
Source: ClinicalTrials.gov · Last updated 27 May 2026
Brief summary (registry, in English)
The KBASE2 is the second phase of the KBASE project, which consists of roll-over participants from the first phase of the KBASE as well as newly enrolled participants with varying degrees of cognitive functions (e.g. individuals with normal cognition, mild cognitive impairment, or AD dementia). In addition to the aims of the first phase of the KBASE, the KBASE2 will focus on new data collection and integrative analysis of the rich structural, functional, and molecular neuroimaging data in relation to whole genome sequencing and other -omics. Network analysis of disruption in brain connectivity in relation to clinical status and AD biomarker profiles also will be conducted.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 640 (estimated)
- First submitted
- 23 Oct 2021
- Start date
- 1 Jan 2022
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Seoul National University Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT05138263
What you commit to
- Study type: Observational
- Planned participants: 640
- From 1 Jan 2022 to the primary completion date, 30 Sept 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking investigational drug
Other illness
- Past history or presence of major psychiatric illness (e.g. schizophrenia, bipolar disorder, alcohol/substance abuse or dependence, delirium)
- Significant neurologic or medical condition that can influence the mental state
Other
- \[Exclusion criteria: general\]
- Contraindications for MRI scan (e.g. pacemaker, claustrophobia)
- Illiteracy
- Significant visual or hearing difficulty
- In pregnancy or breast-feeding
Who the study is looking for
- \[Inclusion criteria: AD\]
- Age : 55 - 90
- Clinical Dementia Rating (CDR)=0.5 or 1
- Diagnostic and Statistical Manual-IV(DSM-IV) criteria for dementia
- National Institute of Aging and the Alzheimer's Association (NIA-AA) Probable AD dementia
- Study partner or caregiver to accompany patient to all scheduled visits
- Written informed consent
- \[Inclusion criteria: MCI (amnestic)\]
- Age : 55 - 90
- Clinical Dementia Rating (CDR)=0.5
- Concern regarding a change in cognition (obtained from the subject, from an informant who knows the subject, or from a skilled clinician observing the subject)
- Lower performance in any cognitive domain that is greater than would be expected for the subject's age and educational background
- Preservation of independence in functional abilities
- Study partner or caregiver to accompany subject to all scheduled visits
- Written informed consent
- \[Inclusion criteria: Elderly normal controls\]
- Age : 55 - 90
- Clinical Dementia Rating (CDR)=0
- Those with contactable Informant
- Written informed consent
- \[Inclusion criteria: Young normal controls\]
- Age : 20 - 54
- Clinical Dementia Rating (CDR)=0
- Written informed consent
Criteria the registry did not label
- Participants will be classified as either Alzheimer's disease(AD) group, mild cognitive impairment(MCI) group, elderly normal controls or young normal controls. Specific inclusion criteria for each group is described below.
Age in the registry: 20 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| SMG-SNU Boramae Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.