NCT05140421Completed
Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program
Strengthening the Safety Net: Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The Ryan White HIV/AIDS Program (RWHAP) for low-income people with HIV (PWH) is a key resource for reducing HIV health disparities and scaling up evidence-based interventions. As RWHAP serves \>50% of US PWH, RWHAP outcomes are vital to achieving "getting-to-zero"/ Ending the HIV Epidemic (EHE) Plan targets. As a grantee for RWHAP Part A (RWPA) funding distributed to the counties/cities severely affected by HIV, New York City (NYC) conducts regular HIV care continuum monitoring citywide and in its RWPA programs, which offer support services to reduce social and behavioral barriers to care/treatment. Local data consistently show lower viral suppression (VS) among RWPA clients in HIV care than among non-RWPA PWH in HIV care. Relative to NYC HIV cases overall, NYC RWPA clients (\~14,000 per year) over-represent Black and Latinx PWH and high-poverty neighborhoods. To address local outcome disparities and to fill gaps left by data-to-care strategies and research focused on medical care (re-)linkage, the investigators propose to implement and rigorously evaluate the effectiveness of a novel 'data-to-suppression' (D2S) intervention among RWPA behavioral health and housing program clients who are in HIV care but unsuppressed. Surveillance-based reports on unsuppressed clients plus D2S capacity-building assistance will guide RWPA providers in targeting and delivering evidence-informed strategies to improve VS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 1494 (actual)
- First submitted
- 19 Nov 2021
- Start date
- 15 Dec 2021
- Primary completion date
- 1 Jun 2024
- Lead sponsor
- City University of New York
- Diseases
- HIV
- NCT number
- NCT05140421
What you commit to
- Study type: Interventional
- Participants enrolled: 1494
- From 15 Dec 2021 to the primary completion date, 1 Jun 2024
- 27 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Agencies without current NYC RWPA funding for housing assistance or behavioral health (mental health, supportive counseling or harm reduction) services are excluded. Agencies with \<5 clients meeting the above inclusion criteria over three recent pre-implementation sample periods of data are also excluded (due to insufficient numbers of unsuppressed clients). Clients enrolled in NYC RWPA behavioral health or housing programs are excluded from the trial if they are virally suppressed, deceased, or lacking any evidence of NYC HIV care for a full year at the time a D2S report is issued. Given the potential lag in reporting to surveillance and the need to use the freshest available surveillance data for D2S reports, some clients may later be found to have died or to have a VL\<200 dated after their qualifying VL≥200 but prior to D2S report generation; such clients will be excluded post hoc from that round of follow-up due to VS at the time of intervention. Similarly, clients later reported (in programmatic data) to have been closed out of all eligible programs before the report issue date will be excluded post hoc.
Who the study is looking for
- For each stepped-wedge implementation period (Period 0, 1, or 2), clients eligible for trial inclusion must have: (1) ≥1 viral load (VL) test in the report year (evidence that they are in HIV care in NYC); (2) unsuppressed VL (≥200 copies/mL) at last reported VL test during that year; and (3) a reported service in one of the eligible programs/agencies during the report year. In addition, they must still have an open RWPA enrollment in one of the eligible programs and agencies and be presumed living at the time of report generation (two months following the end of the report year on which data are being shared with providers).
Sex: All · Does not accept healthy volunteers
Sites (27)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NYC Health and Hospitals Woodhull Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| The Institute for Family Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| BronxWorks, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Housing Works Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Interfaith Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Bridging Access to Care, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Bailey House, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Alliance for Positive Change Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| NYC Health and Hospitals Harlem Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mount Sinai Beth Israel Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Tolentine Zeiser Community Life Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| New York - Presbyterian Hospital Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| St. Ann's Corner of Harm Reduction Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Harlem United Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| New York Harm Reduction Educators, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| La Nueva Esperanza, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Boom!Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Exponents, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| GMHC Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| African Services Committee, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Project Hospitality, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| CAMBA, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Planned Parenthood of Greater New York Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| NYC Health and Hospitals Queens Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| AIDS Center of Queens County, Inc. Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| After Hours Project Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Research Foundation of State University of New York Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.