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NCT05140421Completed

Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

Strengthening the Safety Net: Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

Source: ClinicalTrials.gov · Last updated 4 Nov 2026

Brief summary (registry, in English)

The Ryan White HIV/AIDS Program (RWHAP) for low-income people with HIV (PWH) is a key resource for reducing HIV health disparities and scaling up evidence-based interventions. As RWHAP serves \>50% of US PWH, RWHAP outcomes are vital to achieving "getting-to-zero"/ Ending the HIV Epidemic (EHE) Plan targets. As a grantee for RWHAP Part A (RWPA) funding distributed to the counties/cities severely affected by HIV, New York City (NYC) conducts regular HIV care continuum monitoring citywide and in its RWPA programs, which offer support services to reduce social and behavioral barriers to care/treatment. Local data consistently show lower viral suppression (VS) among RWPA clients in HIV care than among non-RWPA PWH in HIV care. Relative to NYC HIV cases overall, NYC RWPA clients (\~14,000 per year) over-represent Black and Latinx PWH and high-poverty neighborhoods. To address local outcome disparities and to fill gaps left by data-to-care strategies and research focused on medical care (re-)linkage, the investigators propose to implement and rigorously evaluate the effectiveness of a novel 'data-to-suppression' (D2S) intervention among RWPA behavioral health and housing program clients who are in HIV care but unsuppressed. Surveillance-based reports on unsuppressed clients plus D2S capacity-building assistance will guide RWPA providers in targeting and delivering evidence-informed strategies to improve VS.

Status (registry)
Completed
Study type
Interventional
Enrollment
1494 (actual)
First submitted
19 Nov 2021
Start date
15 Dec 2021
Primary completion date
1 Jun 2024
Lead sponsor
City University of New York
Diseases
HIV
NCT number
NCT05140421

What you commit to

  • Study type: Interventional
  • Participants enrolled: 1494
  • From 15 Dec 2021 to the primary completion date, 1 Jun 2024
  • 27 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Agencies without current NYC RWPA funding for housing assistance or behavioral health (mental health, supportive counseling or harm reduction) services are excluded. Agencies with \<5 clients meeting the above inclusion criteria over three recent pre-implementation sample periods of data are also excluded (due to insufficient numbers of unsuppressed clients). Clients enrolled in NYC RWPA behavioral health or housing programs are excluded from the trial if they are virally suppressed, deceased, or lacking any evidence of NYC HIV care for a full year at the time a D2S report is issued. Given the potential lag in reporting to surveillance and the need to use the freshest available surveillance data for D2S reports, some clients may later be found to have died or to have a VL\<200 dated after their qualifying VL≥200 but prior to D2S report generation; such clients will be excluded post hoc from that round of follow-up due to VS at the time of intervention. Similarly, clients later reported (in programmatic data) to have been closed out of all eligible programs before the report issue date will be excluded post hoc.

Who the study is looking for

  • For each stepped-wedge implementation period (Period 0, 1, or 2), clients eligible for trial inclusion must have: (1) ≥1 viral load (VL) test in the report year (evidence that they are in HIV care in NYC); (2) unsuppressed VL (≥200 copies/mL) at last reported VL test during that year; and (3) a reported service in one of the eligible programs/agencies during the report year. In addition, they must still have an open RWPA enrollment in one of the eligible programs and agencies and be presumed living at the time of report generation (two months following the end of the report year on which data are being shared with providers).

Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (27)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
NYC Health and Hospitals Woodhull
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New YorkUnited StatesUnknown status
The Institute for Family Health
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New YorkUnited StatesUnknown status
BronxWorks, Inc.
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New YorkUnited StatesUnknown status
Housing Works
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New YorkUnited StatesUnknown status
Interfaith Medical Center
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New YorkUnited StatesUnknown status
Bridging Access to Care, Inc.
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New YorkUnited StatesUnknown status
Bailey House, Inc.
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New YorkUnited StatesUnknown status
Alliance for Positive Change
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New YorkUnited StatesUnknown status
NYC Health and Hospitals Harlem
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New YorkUnited StatesUnknown status
Mount Sinai Beth Israel
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New YorkUnited StatesUnknown status
Tolentine Zeiser Community Life Center
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New YorkUnited StatesUnknown status
New York - Presbyterian Hospital
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New YorkUnited StatesUnknown status
St. Ann's Corner of Harm Reduction
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New YorkUnited StatesUnknown status
Harlem United
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New YorkUnited StatesUnknown status
New York Harm Reduction Educators, Inc.
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New YorkUnited StatesUnknown status
La Nueva Esperanza, Inc.
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New YorkUnited StatesUnknown status
Boom!Health
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New YorkUnited StatesUnknown status
Exponents, Inc.
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New YorkUnited StatesUnknown status
GMHC
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New YorkUnited StatesUnknown status
African Services Committee, Inc.
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New YorkUnited StatesUnknown status
Project Hospitality, Inc.
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New YorkUnited StatesUnknown status
CAMBA, Inc.
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New YorkUnited StatesUnknown status
Planned Parenthood of Greater New York
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New YorkUnited StatesUnknown status
NYC Health and Hospitals Queens
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New YorkUnited StatesUnknown status
AIDS Center of Queens County, Inc.
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New YorkUnited StatesUnknown status
After Hours Project
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New YorkUnited StatesUnknown status
Research Foundation of State University of New York
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New YorkUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.