NCT05145309Not yet recruitingPhase 2
Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
In the DASH (Dietary Approaches to Stop Hypertension) trials, a diet rich in fruits, vegetables, nuts and dairy products, and limited in fat content, was shown to be useful in controlling hypertension, particularly in African Americans (AA). Key components of such a diet are potassium, magnesium, and alkali, each of which has been implicated in lowering blood pressure. In the original IND 116,208, the investigators explored whether potassium-magnesium citrate (KMgCit) as a powder pharmaceutical formulation (dissolved in water before ingestion) could serve as a surrogate for the DASH diet and would lower blood pressure among patients with pre- or Stage I hypertension. Unfortunately, previous studies did not include adequate number of African American patients.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 10 Nov 2021
- Start date
- Nov 2026
- Primary completion date
- Dec 2031
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- High blood pressure
- NCT number
- NCT05145309
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 45
- From Nov 2026 to the primary completion date, Dec 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with diuretics, including spironolactone
- Gastroesophageal reflux disease (GERD) requiring treatment with acid reducing agent or antacid more than once a week,
Other illness
- Diabetes mellitus,
- Any heart diseases such as congestive heart failure or sustained arrhythmia,
- Esophageal-gastric ulcer,
- History of major depression, bipolar disorder, or schizophrenia, and
- History of substance abuse.
Lab values
- Renal impairment (serum creatinine \> 1.4 mg/dL),
- Hyperkalemia (serum K \> 5.0 mmol/L),
- Abnormal liver function test (AST or ALT above upper limit of normal range),
- Subjects who require any potassium supplement on a regular basis for any reason,
Other
- Chronic NSAID use,
- Chronic diarrhea,
- Pregnancy,
Who the study is looking for
- -African American patients with pre- or Stage I hypertension, with systolic blood pressure of 120-139 mm or diastolic BP of \< 90 mmHg.
Age in the registry: 21 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Texas Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.