NCT05148494RecruitingPhase 4
TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
Transanal Endoscopic Surgery: a Randomized Controlled Trial Comparing Fleet Enema vs Oral Mechanical Bowel Prep (TESEO Trial)
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
There is no consensus about the best bowel preparation prior to transanal endoscopic surgery TES). Cleanliness and visibility in the rectosigmoid and rectum are of utmost importance, possibly even more so than during colonoscopy, to facilitate safe, precise and efficient resection of the rectal lesion and potentially adequate closure of the defect. Both Fleet enemas and oral mechanical bowel preparation are considered standard of care in preparation for TES. This single center two arm single blinded randomized controlled trial will compare the effectiveness of Fleet enemas in comparison to Pico Salax oral mechanical bowel preparation in cleansing the rectum as measured by a modified version of the Ottawa Bowel Prep Scale.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- First submitted
- 25 Nov 2021
- Start date
- 16 Mar 2022
- Primary completion date
- 1 Aug 2027
- Lead sponsor
- Nova Scotia Health Authority
- Diseases
- Colorectal cancer
- NCT number
- NCT05148494
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 66
- From 16 Mar 2022 to the primary completion date, 1 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- previous pelvic radiation
- repeat transanal surgery for the same lesion
- chronic steroid use
- Transanal Endoscopic Surgery combined with another surgical procedure
Other illness
- inflammatory bowel disease
- clear diagnosis of congestive heart failure
Age
- age over 75
Other
- chronic constipation not well controlled with diet or stool softening agents
- patient unable to self-administer enemas
- patient unable to tolerate either of the 2 bowel preps due to medical reasons
- daily use of Lasix or similar loop diuretic
Who the study is looking for
- undergoing transanal endoscopic surgery at the QEII Health Sciences Center in Halifax by one of the colorectal trained surgeons
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Victoria General Hospital Coordinator of this site? Confirm its status | Halifax | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.