Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer

Other illness

• patients with history of mental illness;
• patients combined with other malignancies;
• Active period of disease caused by bacteria, fungi or viruses; and these severe infection requiring intravenous antibiotics,antifungal or antiviral therapy;
• Patients with serious cardiovascular disease ,including uncontrolled hypertension, unstable angina,history of myocardial infarction within the past 12 months,and severe arrhythmias.
• Patients with poorly controlled diabetes who are judged to be unfit for chemotherapy by doctors.
• History of hepatitis and cirrhosisi ;

Other

• pregnant, lactating patients;
• Patients with poor compliance；
• Researchers believe that it is not appropriate to participate in this test.

• Informed consent (radiation, medication) before treatment;
• Age 18 to 70 years old,regardless of gender;
• Initial SCLC confirmed by histopathological or cytological examination;
• Metastatic lesions in the distant area: included liver metastasis；
• Physical status score ECOG: 0 to 2；
• The expected survival time is more than 3 months;
• Bone marrow function:hemoglobin(HGB)\>90g/L,platelet(PLT)\>100×109/L,neutrophil cell(WBC)\>1.5×109/L(\*normal value);
• Liver function:alanine aminotransferase(ALT) and aspertate aminotransferase(AST)\<1.5 times of the upper limit of normal(ULN);Total bilirubin \<1.5ULN;
• Renal function:Serum creatinine was lower than 1.5ULN,and the endogenous creatinine clearance rate(Ccr) is higher than 55mL/min;
• Initial treatment (previously did not receive any thoracic radiotherapy or surgery).