NCT05152992Completed
Spatiotemporal Dynamics of the Human Emotion Network
Source: ClinicalTrials.gov · Last updated 15 Sept 2026
Brief summary (registry, in English)
The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms. Affective symptoms are a common feature of neuropsychiatric disorders that reflect dysfunction in a distributed brain network that supports emotion. How aberrant functioning in a single emotion network underlies a wide range of affective symptoms, such as depression and anxiety, is not well understood. Anchored by the anterior cingulate cortex and ventral anterior insula, the emotion network responds to numerous affective stimuli. The recording of neural activity directly from the cortical surface from individuals is a promising approach since intracranial electroencephalography (iEEG) can provide direct estimates of neuronal populations to map the spatiotemporal dynamics of the emotion network at a millisecond level resolution. This study will exam how activity within emotion network hubs changes during emotions and how emotion network properties make some individuals more vulnerable to affective symptoms than others. A multidisciplinary approach is critical for understanding the dynamic brain network to advance neuroanatomical models of emotions and for guiding the development of novel treatments for affective symptoms.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 70 (actual)
- First submitted
- 29 Nov 2021
- Start date
- 20 Apr 2015
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- University of California, San Francisco
- Diseases
- Epilepsy
- NCT number
- NCT05152992
What you commit to
- Study type: Interventional
- Participants enrolled: 70
- From 20 Apr 2015 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Participants who lack capacity or decline to provide informed consent,
- Participants who have significant cerebral lesions or
- Participants with cognitive deficits that preclude reliable completion of study tasks.
Who the study is looking for
- Participants with epilepsy at UCSF undergoing surgical electrode implantation for seizure localization and
- Participants with electrodes implanted in at least two regions of interest who are willing and able to cooperate with study tasks.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.