NCT05154513Completed
Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV
Source: ClinicalTrials.gov · Last updated 13 Jan 2026
Brief summary (registry, in English)
IMPAACT 2028 is an observational prospective study to characterize a cohort of early treated children who may participate in future research related to HIV remission or cure. Up to approximately 250 participants will be in the study for approximately seven years. No intervention is provided in the study.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 163 (actual)
- First submitted
- 4 Mar 2021
- Start date
- 2 Feb 2022
- Primary completion date
- 30 Jul 2025
- Lead sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
- Diseases
- HIV
- NCT number
- NCT05154513
What you commit to
- Study type: Observational
- Participants enrolled: 163
- From 2 Feb 2022 to the primary completion date, 30 Jul 2025
- 28 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has any documented or suspected clinically significant medical condition or any other condition that, in the opinion of the site investigator, would make participation in the study unsafe or otherwise interfere with completing study procedures
Who the study is looking for
- Participated in one of the parent studies
- Confirmed HIV-1 infection based on documented nucleic acid testing of two blood samples collected at different time points
- Received early treatment for HIV-1 infection, defined as treatment with at least three ARV agents from at least two classes of ART, initiated within 12 weeks of birth
- Based on parent or guardian report at entry, child is expected to be available for at least 24 months of follow-up
- Parent or guardian is willing and able to provide written informed consent for child's study participation and, when applicable per institutional review board/ethics committee (IRB/EC) policies and procedures, child is willing and able to provide written assent for study participation
Sex: All · Does not accept healthy volunteers
Sites (28)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| School of Medicine, University of Minas Gerais - FUNDEP (5073) Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| 5071, Instituto de Puericultura e Pediatria Martagao Gesteira Clinical Research Site Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Hospital Geral De Nova Igaucu (5097) Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Hospital dos Servidores Rio de Janeiro Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Ribeirao Preto Medical School, University of Sao Paulo (5074) Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Gaborone CRS 12701 Coordinator of this site? Confirm its status | Gaborone | Botswana | Unknown status |
| Molepolole Prevention/Treatment Trials CRS 12702 Coordinator of this site? Confirm its status | Molepolole | Botswana | Unknown status |
| Les Centres GHESKIO (30022) Coordinator of this site? Confirm its status | Port-au-Prince | Haiti | Unknown status |
| 5121, Kenya Medical Research Institute/Walter Reed Project Clinical Research Center Kericho Clinical Research Site Coordinator of this site? Confirm its status | Kericho | Kenya | Unknown status |
| College of Med. JHU CRS (30301) Coordinator of this site? Confirm its status | Blantyre | Malawi | Unknown status |
| University of North Carolina Lilongwe (12001) Coordinator of this site? Confirm its status | Lilongwe | Malawi | Unknown status |
| Siriraj Hospital Mahidol University CRS (5115) Coordinator of this site? Confirm its status | Bangkok | Thailand | Unknown status |
| Chiang Rai Regional Hospital (5116) Coordinator of this site? Confirm its status | Chiang Rai | Thailand | Unknown status |
| Kilimanjaro Christian Medical Centre (5118) Coordinator of this site? Confirm its status | Moshi | Tanzania | Unknown status |
| - Coordinator of this site? Confirm its status | Kampala | Uganda | Unknown status |
| 5030, Emory University School of Medicine Clinical Research Site Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| University of Colorado (5052) Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| 5055, South Florida CDTC Fort Lauderdale Clinical Research Site Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| 5128, Texas Children's Hospital Clinical Research Site Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| David Geffen School of Medicine at UCLA (CRS 5112) Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Univ of Miami Pediatric/Perinatal HIV/AIDS (5127) Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Durban | South Africa | Unknown status |
| 8051, Wits RHI Shandukani Research Centre Clinical Research Site Coordinator of this site? Confirm its status | Johannesburg | South Africa | Unknown status |
| Soweto IMPAACT CRS (8052) Coordinator of this site? Confirm its status | Johannesburg | South Africa | Unknown status |
| Family Clinical Research Unit (FAM-CRU) CRS (8950) Coordinator of this site? Confirm its status | Tygerberg Hills | South Africa | Unknown status |
| St. Mary's CRS 30303 Coordinator of this site? Confirm its status | Chitungwiza | Zimbabwe | Unknown status |
| Seke North CRS 30306 Coordinator of this site? Confirm its status | Chitungwiza | Zimbabwe | Unknown status |
| Harare Family Care (31890) Coordinator of this site? Confirm its status | Harare | Zimbabwe | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.