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NCT05163600Recruiting

The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)

The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR):4 Randomized Crossover Studies

Source: ClinicalTrials.gov · Last updated 7 Jul 2026

Brief summary (registry, in English)

The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
24 (estimated)
First submitted
3 Dec 2021
Start date
20 May 2022
Primary completion date
31 Dec 2026
Lead sponsor
University of Zurich
Diseases
COPD
NCT number
NCT05163600

What you commit to

  • Study type: Interventional
  • Planned participants: 24
  • From 20 May 2022 to the primary completion date, 31 Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Physical or intellectual impairment precluding informed consent or protocol adherence
  • History of thromboembolic event in the lower extremity
  • Physical or intellectual impairment precluding informed consent or protocol adherence
  • History of thromboembolic event in the lower extremity

Other

  • Non-German speaking (precluding informed consent)
  • Pain during exercise of any origin
  • Pregnancy
  • Resting systolic blood pressure \<100 mmHg
    • Inclusion and exclusion for the COPD participants are defined by the following criteria.
  • Non-German speaking (precluding informed consent)
  • Acute or recent (within the last 6 weeks) exacerbation of COPD
  • Pain during exercise of any origin
  • Pregnancy
  • Resting systolic blood pressure \<100 mmHg

Who the study is looking for

  • Age ≥ 18 years
  • Clinically healthy
  • Age ≥ 18 years
  • Diagnosed COPD according to GOLD-guidelines12

Criteria the registry did not label

  • Inclusion and exclusion for the healthy participants are defined by the following criteria.

Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University Hospital Zurich
Coordinator of this site? Confirm its status		ZurichSwitzerlandRecruiting

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.