NCT05164718Completed
The Norwegian Exercise in Atrial Fibrillation Trial
The Norwegian Exercise in Atrial Fibrillation Trial - An Open-label, Multicenter Randomized Controlled Trial Comparing an eHealth-based Exercise Intervention With Usual Care After 12 Months Follow-up
Source: ClinicalTrials.gov · Last updated 8 Jul 2026
Brief summary (registry, in English)
Atrial fibrillation (AF) patients suffer a high symptom burden and reduced quality of life (QoL), high hospitalization rates and few effective treatment options. They have a high burden of cardiovascular risk factors and events. Lifestyle changes and exercise is a cornerstone of management in most chronic cardiac conditions and holds promise in AF, but the evidence is sparse and specific guidelines for exercise do not exist for AF patients. NEXAF is a large-scale multicenter randomized trial to determine the feasibility and effects of exercise on patient-reported and clinical outcomes. All patients will undergo continuous rhythm monitoring, enabling assessment of duration, frequency and total time of AF episodes. The overall aim of the study is to provide documentation for clinical exercise recommendations in AF. The objectives are to examine the effects of a 1-year exercise intervention in AF patients on (i) QoL and symptom burden, (ii) time-in-AF, and peak oxygen uptake, cardiac structure and function, cardiovascular risk factors and use of healthcare resources.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 300 (actual)
- First submitted
- 18 Nov 2021
- Start date
- 4 Feb 2022
- Primary completion date
- 4 Jul 2025
- Lead sponsor
- Norwegian University of Science and Technology
- Diseases
- Atrial fibrillation
- NCT number
- NCT05164718
What you commit to
- Study type: Interventional
- Participants enrolled: 300
- From 4 Feb 2022 to the primary completion date, 4 Jul 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Alcohol or drug abuse
Other illness
- AF as a complication of acute coronary syndromes, cardiothoracic surgery or infections
- Unstable coronary heart disease
- De-compensated heart failure
- Moderate to severe chronic obstructive pulmonary disease (GOLD group C+D)
- Ongoing severe cancer or active cancer treatment
- Cognitive or serious psychiatric disease that may impede protocol compliance
- Physical impairments or diseases hindering exercise or making exercise contraindicated
Lab values
- Left ventricular ejection fraction \<40%
Other
- Permanent AF or persistent AF with at least one continuous episode lasting ≥3 months the last year
- Planned ablation procedure next 12 months or ablated last 6 months without known recurrence
- At least moderate to severe mitral or aortic pathology, or aortic aneurysms clinically incompatible with safe exercise
- Pacemaker or ICD
- Pregnancy
- Resident of nursing home or other institution
- Participation in conflicting research studies (i.e. lifestyle interventions)
Who the study is looking for
- Signed informed consent
- Diagnosed with paroxysmal or persistent AF in hospital registries
- In sinus rhythm at baseline screening
- Report \<75 minutes per week of vigorous and/or \<150 minutes of moderate intensity exercise the last three months
- Use a smartphone
Age in the registry: 18 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vestre Viken HF Coordinator of this site? Confirm its status | Drammen | Norway | Unknown status |
| University Hospital of North Norway Coordinator of this site? Confirm its status | Tromsø | Norway | Unknown status |
| St Olavs Hospital Coordinator of this site? Confirm its status | Trondheim | Norway | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.