NCT05165706Recruiting
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Source: ClinicalTrials.gov · Last updated 4 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clinical indices with cellular changes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 3 Jul 2018
- Start date
- 31 Jan 2019
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- Stanford University
- NCT number
- NCT05165706
What you commit to
- Study type: Interventional
- Planned participants: 110
- From 31 Jan 2019 to the primary completion date, 30 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of weight loss medication, statins, or oral steroids
- Clinical screening exclusions;
Other illness
- diabetes
- major organ disease
- history of liposuction or bariatric surgery
- active eating or psychiatric disorder
Lab values
- fasting glucose \>/= 126 mg/dL
Other
- Patients with;
- pregnancy or lactation, heavy alcohol use
- recent change in weight (over the past 12 weeks)
- hematocrit \< 33%
- blood pressure \>160/100 mmHg
Who the study is looking for
- Age 35-65
- BMI 25-35 kg/m2
- Stable body weight
- Nondiabetic
Age in the registry: 35 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.