NCT05169827Completed
Cerebral Contributions to Symptom Progression in PD
How Cerebral Plasticity Shapes Symptom Progression in Parkinson's Disease: a Longitudinal Neuroimaging Study
Source: ClinicalTrials.gov · Last updated 21 Feb 2025
Brief summary (registry, in English)
Motor symptom progression in early-stage Parkinson's disease varies substantially between individual patients. This progression correlates poorly with striatal dopamine depletion, which is largely complete four years post-diagnosis. Identification of alternative mechanisms, such as cortical compensatory processes, may enable more accurate predictions of individual motor progression.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 115 (actual)
- First submitted
- 30 Mar 2021
- Start date
- 1 Dec 2019
- Primary completion date
- 28 Nov 2023
- Lead sponsor
- Radboud University Medical Center
- Diseases
- Parkinson disease
- NCT number
- NCT05169827
What you commit to
- Study type: Observational
- Participants enrolled: 115
- From 1 Dec 2019 to the primary completion date, 28 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subject is not taking dopaminergic medication
Other illness
- Subject has no co-morbidities that would negatively influence the interpretability of results from a comparison with PD patients (e.g. other neurodegenerative diseases or mental health disorders)
Who the study is looking for
- Subject is included in the Personalized Parkinson Project and has already participated in all baseline measurements (this means that inclusion and exclusion criteria of the Personalized Parkinson Project have already been fulfilled)
- Subject has completed the Informed Consent Form, as approved by the Ethics Committee
- Subject is at least 40 years old
- Subject can read and understand Dutch
- Subject has completed the Informed Consent Form, as approved by the Ethics Committee
- Subject is willing, competent, and able to comply with all aspects of the protocol, including follow-up schedule.
Age in the registry: 40 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Donders institute for brain, cognition and behaviour Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.