NCT05174351Recruiting
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 29 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 2 Dec 2021
- Start date
- 20 Dec 2021
- Primary completion date
- 1 Nov 2027
- Lead sponsor
- UConn Health
- Diseases
- Heart failure
- NCT number
- NCT05174351
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 20 Dec 2021 to the primary completion date, 1 Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
- Heart rate \> 100 bpm
Other
- Recent hospitalization due to HF within 3 months
- Non-English speaker
Who the study is looking for
- Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
- N=30 (Target: 30).
- Age: 50 \~ 80 years.
- ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
- Chronic loop diuretic use
- Currently on beta-blocker
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UConn Health / John Dempsey Hospital Coordinator of this site? Confirm its status | Farmington | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.