NCT05175248Active, not recruiting
Nutritional Intervention for Endometriosis
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
In a 12-week parallel study, women with a verified diagnosis of endometriosis will be randomly assigned to follow a low-fat plant-based diet or to stay on their usual diets for 12 weeks. Participants in both groups will be asked to make no changes to their exercise patterns for the study period. Changes in pain, quality of life, and inflammatory biomarkers from baseline to final will be the primary outcomes. Secondary outcomes will include changes in body weight, blood lipids, gut microbiome composition, and hormonal changes.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 14 Dec 2021
- Start date
- 2 Mar 2022
- Primary completion date
- Dec 2029
- Lead sponsor
- Physicians Committee for Responsible Medicine
- Diseases
- Endometriosis
- NCT number
- NCT05175248
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 2 Mar 2022 to the primary completion date, Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Smoking or drug abuse during the past six months
Other illness
- Alcohol consumption of more than 2 drinks per day or the equivalent, episodic increased drinking (e.g., more than 2 drinks per day on weekends), or a history of alcohol abuse or dependency followed by any current use
- Unstable medical or psychiatric illness
- Fibroids, ovarian cysts, pelvic inflammatory disease
- Endocrine inflammatory conditions, such as Cushing's syndrome, Hashimoto's thyroiditis, Graves' disease, type 1 diabetes mellitus, and Addison's disease
- Evidence of an eating disorder
Other
- Body mass index ≥ 40 kg/m2
- Already following a plant-based diet
- Pregnant or breastfeeding, or plans of pregnancy within the study period
- Hysterectomy or ovariectomy
- Lack of English fluency
- Unable or unwilling to participate in all components of the study
Who the study is looking for
- Women with a surgical, imaging, or clinical diagnosis of endometriosis
- Age 18-45 years
- Stable health condition and medications for past 3 months
- Modified Biberoglu and Behrman (B\&B) pelvic pain score of at least 5/9
- Able to follow a plant-based diet for 12 weeks
- Willing to be randomly assigned to either a plant-based group or a control group that will not make any dietary changes for 12 weeks
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Physicians Committee for Responsible Medicine Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.