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NCT05183737Active, not recruiting

Effects of Microencapsulated Propolis and Turmeric in Patients With Chronic Kidney Disease

Effects of Supplementation With Microcapsules of Tumeric and Propolis on Inflammatory Markers in Patients on Hemodialysis

Source: ClinicalTrials.gov · Last updated 3 Apr 2025

Brief summary (registry, in English)

Oxidative stress and inflammation are correlated with Chronic Kidney Disease (CKD), in a way that they bring several harms to patients, including an increased risk of cardiovascular disease and mortality. Adjuvant therapeutic options such as bioactive compounds present in some foods seem to mitigate inflammation. Turmeric and propolis are foods that have compounds with antioxidant and anti-inflammatory capacity, as they promote the activation of nuclear erythroid transcription factor 2 (Nrf2 - responsible for the synthesis of antioxidant enzymes) and inhibit the activity of nuclear factor Kappa B (NF-κB - which increases the synthesis of inflammatory cytokines). This work aims to evaluate the effects of supplementation of associated propolis and turmeric microcapsules on inflammatory markers in patients with CKD undergoing hemodialysis (HD).

Status (registry)
Active, not recruiting
Study type
Interventional
Enrollment
34 (estimated)
First submitted
11 Aug 2021
Start date
7 Mar 2022
Primary completion date
1 Dec 2024
Lead sponsor
Universidade Federal Fluminense
NCT number
NCT05183737

What you commit to

  • Study type: Interventional
  • Planned participants: 34
  • From 7 Mar 2022 to the primary completion date, 1 Dec 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • With autoimmune and infectious diseases, cancer, liver and AIDS (Acquired Immunodeficiency Syndrome)

Other

  • Pregnant women;
  • Smokers;
  • Using antibiotics in the last 3 months;
  • Using antioxidant supplements;
  • Who have habitual intake of propolis, curcumin and turmeric;

Who the study is looking for

  • Patients with stage 5 CKD (GFR \< 15 mL/min);
  • On hemodialysis for more than 6 months;
  • Who have arteriovenous fistula (AVF) as vascular access

Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Denise mafra
Coordinator of this site? Confirm its status
Rio de JaneiroBrazilUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.