NCT05184361Completed
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain. Therefore, the aim of this study is to evaluate the effects of an intermittent versus a continuous energy restriction in body composition (body weight, fat mass and fat-free mass) and metabolic adaptation, in women with obesity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 75 (actual)
- First submitted
- 17 Dec 2021
- Start date
- 13 Jan 2022
- Primary completion date
- 30 Jun 2024
- Lead sponsor
- Universidade do Porto
- Diseases
- Obesity
- NCT number
- NCT05184361
What you commit to
- Study type: Interventional
- Participants enrolled: 75
- From 13 Jan 2022 to the primary completion date, 30 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous or present health disorders: cancer, autoimmune, cardiac, psychiatric, kidney and liver disease (except liver steatosis), diabetes, chronic intestinal inflammatory disease, or other medical conditions known to affect energy balance homeostasis
- Medications that promote weight gain or alter energy balance, including corticosteroids, antidepressants, anxiolytics, mood-stabilizing, and antipsychotics
- Medications or dietary supplements for weight-loss in the past 3 months
- Surgery or in hospital admission for the last month
Other illness
- Hormonal or thyroid disorder
- Positive for Covid-19 in the past 3 months or testing positive during the intervention phase of the study
Other
- Menopause
- Pregnant for the past 6 months or breastfeeding
- Planning to get pregnant in the next 2 years or getting pregnant during the study
- Current consumption of more than 14 alcoholic drinks per week or other substance abuse, and/or current acute treatment or rehabilitation program for alcohol/substance abuse
Who the study is looking for
- Women
- BMI ranging between 30 and 39.9 kg/m2
- Age between 20-45 years
- Weight stable in the last 6 months (less than 5% weigh variation)
- Inactive (less then 150 min/week of moderate physical activity or 75 min/week of vigorous physical activity
- Living in Lisbon Metropolitan Area and being able to drive to Faculty of Human Kinetics and Germano de Sousa Laboratory (Algés)
- Available to be randomized to any of the trial groups (CER or IER)
- Willing to commit with the assigned group protocol, including the nutritional intervention and lifestyle recommendations, as well as being available for participation in all evaluation moments.
Age in the registry: 20 years to 45 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculdade de Motricidade Humana da Universidade de Lisboa Coordinator of this site? Confirm its status | Cruz Quebrada | Portugal | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.