NCT05194098Completed
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 98 (actual)
- First submitted
- 3 Jan 2022
- Start date
- 1 Oct 2021
- Primary completion date
- 24 Jun 2025
- Lead sponsor
- San Francisco Veterans Affairs Medical Center
- Diseases
- Depression
- NCT number
- NCT05194098
What you commit to
- Study type: Interventional
- Participants enrolled: 98
- From 1 Oct 2021 to the primary completion date, 24 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)
Other illness
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
- Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
- Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
- Past or present DSM-5 (SCID-5) Gambling Disorder
- DSM-5 (SCID-5) criteria for any psychiatric disorder
Other
- Premorbid IQ estimate \< 70
- Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
- Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
- Known claustrophobia
- Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)
- Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
Who the study is looking for
- All participants
- 18-65 years old
- Normal (or corrected to normal) vision
- Participants with MDD
- Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
- Screened for TMS and MRI safety
- On a stable psychiatric medication regime for \> 1 month
Criteria the registry did not label
- Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| San Francisco VA Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.