NCT05195398Recruiting
TDCS to Improve Post-Stroke Cognitive Impairment
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention by individuals on the study team blinded to the participant's intervention. Participants will also undergo functional neuroimaging with magnetoencephalography (MEG) pre- and post-intervention (1, 3, and 6 months post-stroke to evaluate for initial and longer-term effects of treatment on cerebral activation patterns and functional connectivity). Neuroimaging and clinical outcomes will be assessed to determine the effect of tDCS versus sham + CCT on psMCI.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 4 Jan 2022
- Start date
- 1 Sept 2022
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- Johns Hopkins University
- Diseases
- Stroke
- NCT number
- NCT05195398
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Sept 2022 to the primary completion date, 31 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior report or history of dementia or undertreated psychiatric illness.
Other illness
- Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI.
- Presence of any of the following that would lead to significant artifact on MEG: cardiac pacemaker, intracranial clips, metal implants or external clips within 10mm of the head, metal implants in the eyes (unlikely given that all patients will have an MRI and criteria are similar).
Other
- Presence of proximal large vessel occlusion.
- Cortical exam findings including aphasia or neglect.
- Uncorrected hearing or visual loss.
- Inability to attend treatment or follow-up sessions.
- Inability to travel to College Park (UMD) for MEG recording sessions.
- Claustrophobia, obesity, and/or any other reason leading to difficulty staying in the MEG machine for up to 1 hour.
Who the study is looking for
- Adults (≥18 years) presenting with neurological symptoms due to acute ischemic stroke (symptom onset within the week prior to admission).
- Evidence on brain MRI of acute ischemic stroke (imaging negative strokes and TIAs will be excluded).
- Native English speaker (by self-report) prior to stroke.
- NIHSS \<8 at initial follow-up visit (approximately 30 days post-stroke).
- mRS 0-2 at initial follow-up visit.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Bayview Medical Center Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.