Liver Cancer Prevention Randomized Control Trial

Prior treatment

• Recent or planned surgery that would interfere with home-based exercise or a low-fat, high vegetable and fruit diet
• Current or prior history of primary liver cancer or cancer that is metastatic to the liver

Other

• Pregnant or planning to become pregnant in next 12 months (by self-report)
• Medical contraindications to home-based exercise or low-fat, high-vegetable-and-fruit diet
• AUDIT-10 score \>15
• Family or household member already enrolled into study

• 1\. Evidence of steatosis (CAP score ≥ 290 by vibration controlled transient elastography) OR Evidence of liver fibrosis (FIB-4 index ≥ 1.6 or fibrosis grade ≥ F2 by vibration controlled transient elastography \[F2 score ≥ 8kPa\]) AND meets one of the following criteria: i. overweight or obese (BMI≥23 in Asians or BMI≥25 in other racial groups), OR ii. presence of type II diabetes mellitus, OR iii. lean/normal weight with presence of at least two metabolic risk abnormalities, OR:
• Waist circumference ≥90/80 cm in Asians or ≥102/88 cm in other racial groups)
• Blood pressure ≥130/85 mmHg or specific drug treatment
• Plasma triglycerides ≥150 mg/dl or specific drug treatment
• Plasma HDL-cholesterol \<40 mg/dl for men and \<50 mg/dl for women, or specific drug treatment
• Prediabetes (fasting glucose levels 100-125 mg/dl , or HbA1c 5.7-6.4% ) iv. AUDIT-C ≥4 for men and ≥3 for women AND AUDIT-10 = 8-15
  • AND/OR 2. Evidence of liver fibrosis (FIB-4 index ≥ 1.6 or fibrosis grade ≥ F2 by vibration controlled transient elastography) and presence of one of the following:
• chronic HBV (HBsAg+ or taking anti-HBV therapy), or
• chronic HCV (1. detectable HCV RNA \> 4 months or a 2. history of HCV infection and taking anti-HCV therapy)
  • 3\. At least 18 years old 4. Speak and read English or Spanish 5. Access to smartphone with data plan or Wi-Fi access 6. Willing to receive up to 12 text messages per week