NCT05209386Completed
Flexible Representation of Speech
Flexible Representation of Speech in the Supratemporal Plane
Source: ClinicalTrials.gov · Last updated 8 Sept 2025
Brief summary (registry, in English)
The overarching goal of this exploratory research is to understand the dynamic and flexible nature of speech processing in the human supratemporal plane. The temporal lobe has long been established as a region of interest in the speech perception and processing literature because it contains the auditory cortex. More recently, research has localized the supratemporal plane as an area that exhibits response specificity to acoustic properties of complex auditory signals like speech. The supratemporal plane, comprised of Heschl's gyrus, the planum polare, and the planum temporale, is capable of the rapid spectrotemporal analysis required to map acoustic information to linguistic representation. Neural activity in this area, however, is rarely studied directly because it is difficult to access with non-invasive measures like scalp electroencephalography (EEG). Capitalizing on the unique opportunity to access these areas via routine clinical stereoelectroencephalography (sEEG) in a patient population, this study seeks to understand how cortical responses reflect the diagnosticity of two acoustic-phonetic dimensions of interest and how responses rapidly and flexibly adapt to changes in listening demands. Examining how neural response to voice onset time (VOT) and fundamental frequency (F0) modulates as a function of perceptual weight carried in signaling phoneme categories, and identifying how changes in listening context shift perceptual weight, will provide invaluable data that indicates how speech processing flexibly adapts to short-term acoustic patterns.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 48 (actual)
- First submitted
- 12 Jan 2022
- Start date
- 2 May 2022
- Primary completion date
- 1 Jul 2024
- Lead sponsor
- University of Pittsburgh
- Diseases
- Epilepsy
- NCT number
- NCT05209386
What you commit to
- Study type: Interventional
- Participants enrolled: 48
- From 2 May 2022 to the primary completion date, 1 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of autism or ADHD
Other
- Individuals with intellectual disabilities
- Abnormal epileptiform activity in the supratemporal plane
- Lack of fluent English comprehension/production
- Severe language or auditory-specific cognitive dysfunction
Who the study is looking for
- Individuals 15-25 years old
- Undergoing sEEG placement in the supratemporal plane for clinically necessary localization of epileptic foci or language mapping
- Fluent English speakers
- Cognition and speech-language skills within normal limits (as determined by evaluation prior to surgery)
- Normal or correct-to-normal visual acuity
- Normal hearing acuity in each ear (as determined by audiometric assessment)
- No history of autism or ADHD
Age in the registry: 15 years to 25 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UPMC Children's Hospital of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.