NCT05228067Active, not recruiting
Enhancing Brain Health by TDCS in Persons with Overweight and Obesity
Enhancing Brain Health to Prevent Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 30 Mar 2025
Brief summary (registry, in English)
Disturbances in the hypothalamus communication pathways with other regions in the brain and the periphery may represent a potential link between metabolic and cognitive health. The current project evaluates whether enhancing synaptic plasticity of this pathway can improve weight management, insulin sensitivity, and cognitive functions. In recent studies, we were able to show that the human brain is sensitive to insulin with favorable effects on peripheral metabolism and cognition. These brain regions encompass the hypothalamus and its connections to the striatum and prefrontal cortex. We want to investigate whether it is possible to enhance neuroplasticity of insulin-responsive brain regions to suppress the weight gain trajectory and improve dopamine-dependent cognitive functions in people with a high risk to develop type 2 diabetes. For this purpose, neuroimaging tools using high-definition transcranial direct current stimulation (HD-tDCS) and magnetic resonance imaging (MRI) will be implemented to assess synaptic plasticity of a neural network essential for metabolic and cognitive health.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 12 Nov 2021
- Start date
- 8 Nov 2021
- Primary completion date
- 30 Dec 2024
- Lead sponsor
- University Hospital Tuebingen
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT05228067
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 8 Nov 2021 to the primary completion date, 30 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking psychotropic drugs
- Previous bariatric surgery
- Contradictions to a MRI measurement (e.g. metal implants)
Other illness
- History of severe mental or somatic disorders including neurological diseases (incl. Epileptic seizures)
- Acute infection within the last 4 weeks
Lab values
- Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men
Other
- Insufficient knowledge of the German language
- Persons who cannot legally give consent
- Pregnancy or lactation
- Current participation in a lifestyle intervention study or a pharmaceutical study
Who the study is looking for
- Written consent to participate in the study
- Written consent to be informed about incidental findings
- Overweight and obese participants:
- Body mass index (BMI) between 28 and 39.5 kg/m2
- Age between 20 to 65 years of age
- Waist circumference \> 80 cm for women, \> 94 cm for men
- Sex and age matched normal weight individuals:
- Body mass index (BMI) between 19.5 and 24.5 kg/m2
- Age between 20 to 65 years of age
Age in the registry: 20 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Clinic Tübingen Coordinator of this site? Confirm its status | Tübingen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.