NCT05229705Completed
Exercise in Older Adults at Risk for Type 2 Diabetes
The Effects of Exercise on Cognition and Brain Health in Older Adults at Risk for Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 15 Oct 2024
Brief summary (registry, in English)
Older adults with type 2 diabetes experience neurocognitive decline and are at higher risk for developing dementia. Consequently, older adults at-risk for developing type 2 diabetes (i.e., those who are overweight and/or prediabetic) are at higher risk for neurocognitive decline, and intervening at this point may prevent or delay the onset of such decline. One promising lifestyle intervention that has been shown to improve cognitive function and brain health in other populations is resistance exercise. We previously conducted a 6-month resistance training randomized controlled trial (RCT) pilot study that showed a large scale trial would be viable and feasible. Consequently, we would like to explore resistance exercise as a lifestyle intervention to improve cognition and brain structure in older adults at risk for diabetes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 15 Dec 2021
- Start date
- 23 Sept 2022
- Primary completion date
- 5 Jun 2024
- Lead sponsor
- Western University, Canada
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT05229705
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 23 Sept 2022 to the primary completion date, 5 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently on hormone replacement therapy
- Currently taking psychotropic medications
Other illness
- Current medical condition for which exercise is contraindicated
- Diagnosed with neurodegenerative disease (including dementia, Alzheimer's disease, or Parkinson's disease)
- Experienced a vascular incident (e.g., stroke, myocardial infarction)
- Diagnosed with a psychiatric condition
- Clinically significant peripheral neuropathy or severe musculoskeletal or joint disease
Other
- Participated regularly in resistance or aerobic training in the last 6 months
- Untreated depression and scored 5 or less on the Geriatric Depression Scale
- Cannot blood draw
Who the study is looking for
- Community-dwelling
- Aged 60-80 years
- "At-risk" for diabetes, where they have one of the following: i) blood glucose level of 6.1-7 mmol/L, ii) body mass index \> 25, or iii) score \> 21 on the CANRISK diabetes questionnaire
- Score \> 24/30 on MMSE
- Score \> 6/8 on the IADL scale
- Visual acuity of at least 20/40, with or without corrective lenses
- Speak and understand English fluently
- Complete the PAR-Q
- Obtain physician's clearance to start a supervised exercise program
Age in the registry: 60 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Western University Coordinator of this site? Confirm its status | London | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.