NCT05229822Completed
Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Bowel Obstruction
Prognostic Significance of Bacterial Translocation Markers as Predictors of Infectious and Inflammatory Complications in Acute Mechanical Bowel Obstruction
Source: ClinicalTrials.gov · Last updated 16 Jan 2025
Brief summary (registry, in English)
Despite modern approaches to the diagnosis and treatment of acute bowel obstruction (ABO), postoperative mortality ranges from 5 to 32%, and complications occur up 23% of cases. One of the formidable infectious and inflammatory complications of ABO is sepsis. The main component of the development of sepsis in ABO is bacterial translocation (BT). BT is the migration of intestinal bacteria or their products through the intestinal mucosa into the mesenteric lymph nodes and further into normally sterile tissues and organs. Today there are several methods for detecting BT: 1. direct method - the detection of 16s rRNA (ribosomal ribonucleic acid) in mesenteric lymph nodes (MLN); 2. indirect method - the detection of serum lipopolysaccharide-binding protein (LBP) and presepsin (Soluble CD14 subtype or sCD14-ST). The aim of this study is to determine the diagnostic and prognostic significance of bacterial translocation as a predictor of the complications development in patients with malignant and benign acute bowel obstruction by assessing the relationship of biomarkers in the systemic circulation (LBP, sCD14-ST) with the detection of microorganism genes (16s rRNA) in mesenteric lymph nodes.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 150 (actual)
- First submitted
- 21 Jan 2022
- Start date
- 1 Mar 2021
- Primary completion date
- 31 Oct 2023
- Lead sponsor
- Karaganda Medical University
- Diseases
- Colorectal cancer
- NCT number
- NCT05229822
What you commit to
- Study type: Observational
- Participants enrolled: 150
- From 1 Mar 2021 to the primary completion date, 31 Oct 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- patients with HIV infection, liver cirrhosis,
Age
- age less than 18,
Other
- pregnancy,
- patients with paralytic acute bowel obstruction,
- patient with an infectious process due to another pathology.
Who the study is looking for
- patients with malignant acute bowel obstruction,
- patients with benign acute bowel obstruction,
- colorectal cancer patients without acute bowel obstruction (planned operations).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NJSC Karaganda Medical University Coordinator of this site? Confirm its status | Karaganda | Kazakhstan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.