NCT05230433Completed
High-fat Meal Challenge in Pediatrics
Implications of Insulin Resistance and Cardiorespiratory Fitness in the Metabolic Response to a High-fat Meal Challenge in Pediatrics
Source: ClinicalTrials.gov · Last updated 29 Sept 2025
Brief summary (registry, in English)
The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 6 Jan 2022
- Start date
- 1 May 2022
- Primary completion date
- 19 Sept 2022
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Diseases
- Obesity
- NCT number
- NCT05230433
What you commit to
- Study type: Interventional
- Participants enrolled: 15
- From 1 May 2022 to the primary completion date, 19 Sept 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous diagnosis of type 1 or 2 diabetes.
Other illness
- Evidence of inherited disorders of lipid metabolism.
- Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy.
Lab values
- Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin).
Other
- Inability to participant in the maximal aerobic capacity test on the treadmill.
- Individuals who cannot speak and/or write in English.
Who the study is looking for
- Children ages 8-17 years with a BMI-percentile ≥ 5th.
Age in the registry: 8 years to 17 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dartmouth Health Coordinator of this site? Confirm its status | Lebanon | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.