NCT05230914Recruiting
A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Simple Imaging Versus Standard Imaging Selection in Stroke Patients for Endovascular Treatment: the NO-SELECT Randomized Trial
Source: ClinicalTrials.gov · Last updated 26 Dec 2025
Brief summary (registry, in English)
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy. The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1846 (estimated)
- First submitted
- 27 Jan 2022
- Start date
- 12 Dec 2024
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Xinqiao Hospital of Chongqing
- Diseases
- Stroke
- NCT number
- NCT05230914
What you commit to
- Study type: Interventional
- Planned participants: 1846
- From 12 Dec 2024 to the primary completion date, 30 Jun 2027
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Allergy to radiographic contrast agents, or nitinol devices;
- Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel;
- Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations;
- Any terminal illness with life expectancy less than 6 months;
Other
- Currently pregnant or lactating (women patients);
- Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation);
- Brain tumors with mass effect (except meningiomas) that are radiographically pleasant;
- Intracranial aneurysm, arteriovenous malformation;
- Unlikely to be available for 90-day follow-up.
Who the study is looking for
- Aged 18 years or older;
- The interval time from last known well to hospital arrival is within 24 hours;
- Acute stroke confirmed by clinical symptoms or imaging examination;
- Field Assessment Stroke Triage for Emergency Destination (FAST ED) ≥4;
- Written informed consent is obtained from patients and/or their legal representatives.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xinqiao Hospital of Army Medical University Coordinator of this site? Confirm its status | Chongqing | China | Not yet recruiting |
| Dalian Central Hospital Coordinator of this site? Confirm its status | Dalian | China | Recruiting |
| The First Affiliated Hospital of Hainan Medical University Coordinator of this site? Confirm its status | Haikou | China | Recruiting |
| Huai'an First People's Hospital Coordinator of this site? Confirm its status | Huai'an | China | Recruiting |
| Wuyi Traditional Chinese Medicine Hospital Coordinator of this site? Confirm its status | Jiangmen | China | Not yet recruiting |
| Jingdezhen First People's Hospital Coordinator of this site? Confirm its status | Jingdezhen | China | Recruiting |
| Yijishan Hospital of Wannan Medical College Coordinator of this site? Confirm its status | Wuhu | China | Recruiting |
| The 904th Hospital of CPLA Coordinator of this site? Confirm its status | Wuxi | China | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.