NCT05234463Recruiting
Study of the Link Between Complement Activation and IgA Nephropathy Severity
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
ICONE study (IgA Complement and NEphropathy is a prospective monocentric observational study. The main objective is to evaluate the relevance of complement activation as a biomarker of disease severity and progression in patients with a biopsy proven IgAN.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 31 Jan 2022
- Start date
- 9 May 2022
- Primary completion date
- 1 May 2027
- Lead sponsor
- University Hospital, Strasbourg, France
- Diseases
- IgA nephropathy
- NCT number
- NCT05234463
What you commit to
- Study type: Observational
- Planned participants: 400
- From 9 May 2022 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active or recent infectious or inflammatory syndrome (\<2 months), recent vaccination (\<2 months), ongoing acute humoral rejection treatment, treatment with plasma exchanges (\<2 months), current treatment with complement inhibitors
Other
- Impossibility of giving informed information (emergency situation, difficulties in understanding, etc.)
- Subject under safeguard of justice, guardianship or curatorship
Who the study is looking for
- Adult patients, male or female, with a biopsy proven IgA nephropathy.
- Primitive and secondary forms can be included
- Regardless of the date of diagnosis and the level of kidney function
- With or without past of kidney transplantation
- Followed in the Nephrology Department, Strasbourg University Hospital
- Signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service de néphrologie Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
Related publications
- Association of Complement Genetics with Outcomes in IgA Nephropathy.Clin J Am Soc Nephrol · 2026 · PMID 42138996
This page is information, not medical advice. Discuss any trial with your doctor.