NCT05240352Recruiting
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 4 Feb 2022
- Start date
- Oct 2022
- Primary completion date
- Dec 2026
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Diseases
- Bipolar disorder
- NCT number
- NCT05240352
What you commit to
- Study type: Interventional
- Planned participants: 45
- From Oct 2022 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- substance abuse/dependence and any use of drugs (except alcohol or nicotine) in the previous month of the baseline assessment
- previous neurological conditions (epilepsy, traumatic brain injury, stroke, etc)
Other illness
- participants with personality disorder that would interfere with study participation according to clinical judgment
- any severe, life-threatening non-psychiatric medical condition
Other
- specific contraindications for tDCS (metallic plates in the head)
- Participants identified as acutely suicidal or severely agitated
Who the study is looking for
- diagnosis of Bipolar Disorder and clinically significant anhedonia
- mild symptoms of depression
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Texas Health Science Center at Houston Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.