NCT05248620Recruiting
Prophylactic Antibiotic Treatment in Hemodialysis
Prophylactic Antibiotic Treatment in End Stage Kidney Disease and Central Venous Catheter as Hemodialysis Vascular Access
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to assess the efficacy of prophylactic antibiotic treatment on blood stream infections and severe culture negative infections, in patients on newly started hemodialysis(HD), with a central venous catheter as vascular access.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 800 (estimated)
- First submitted
- 8 Feb 2022
- Start date
- 14 Feb 2022
- Primary completion date
- Oct 2028
- Lead sponsor
- Zealand University Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT05248620
What you commit to
- Study type: Interventional
- Planned participants: 800
- From 14 Feb 2022 to the primary completion date, Oct 2028
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active infection treated with antibiotics
- Pregnancy. In women of childbearing age, an approved birth control must be ensured at least 1 month before and during all the 6 months of antibiotic/placebo treatment.
- Patients may be rescreened later i.e. within a time period of one month from start of HD, if exclusion criteria are reversible.
Other
- Unable to give informed consent
- Known intolerance to beta-lactam antibiotics and clindamycin
- Breastfeeding
Who the study is looking for
- End Stage Kidney Disease (ESKD) patients who receive an uncuffed or cuffed CVC for expected chronic HD, regardless of previous ESKD treatment modality (PD or KTX) and hemodialysis access (AV-fistula or AV-graft))
- ≥18 years
- Ability to understand the study background, risk and benefit of treatment and to give written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aalborg University Hospital Coordinator of this site? Confirm its status | Aalborg | Denmark | Recruiting |
| Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus | Denmark | Not yet recruiting |
| Herlev-Gentofte Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen | Denmark | Not yet recruiting |
| North Zealand Hospital, Hillerød Coordinator of this site? Confirm its status | Hillerød | Denmark | Not yet recruiting |
| Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
| ZUH Roskilde Coordinator of this site? Confirm its status | Roskilde | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.