NCT05258396Recruiting
Exploring Cortical Remyelination in Children With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 17 Feb 2022
- Start date
- 11 Aug 2022
- Primary completion date
- 11 Sept 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Multiple sclerosis
- NCT number
- NCT05258396
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 11 Aug 2022 to the primary completion date, 11 Sept 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Parental rejection
- Contre-indication of brain MRI: pace maker, tatoo of the face, claustrophobia….
- Pregnancy, copper intrauterine device
Who the study is looking for
- age between 12 years old and 18 years old
- RR-MS defined by 2017 McDonald criteria
- no relapse the last 4 weeks
- no methylprednisolone or prednisolone the last 4 weeks.
- affiliated to the social security system
- signature of the consent by the 2 holders of parental authority
- age between 12 years old and 18 years old
- absence of any neurological
- signature of the consent by the 2 holders of parental authority
Age in the registry: 12 years to 18 years · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service de Neurologie Pédiatrique, Hôpital du Kremlin Bicêtre Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Recruiting |
| Service de Neurologie, GH Pitié Salpêtrière Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| CIC Neurosciences - Pitié Salpêtrière Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.