NCT05265520Recruiting
His-Bundle Corrective Pacing in Heart Failure
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 10 Feb 2022
- Start date
- 2 Dec 2022
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- University of Rochester
- Diseases
- Heart failure
- NCT number
- NCT05265520
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 2 Dec 2022 to the primary completion date, 1 Jul 2027
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization
Other illness
- On heart transplant list or likely to undergo heart transplant
Other
- Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology
- Unable or unwilling to follow study protocol
- Less than 12 months life expectancy at consent
- Pregnancy or planned pregnancy during duration of the study
Who the study is looking for
- Age 18 years or older (no upper age limit)
- Optimal medical therapy for heart failure by current guidelines
- Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:
- New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR
- NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR
- NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mission Health Coordinator of this site? Confirm its status | Asheville | United States | Recruiting |
| University of Vermont Coordinator of this site? Confirm its status | Burlington | United States | Recruiting |
| Northwestern Memorial Hospital Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Mount Sinai Hospital Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Weill Cornell Medical College Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| University of Arizona Coordinator of this site? Confirm its status | Phoenix | United States | Recruiting |
| Virginia Commonwealth University Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| Valley Health System Coordinator of this site? Confirm its status | Ridgewood | United States | Recruiting |
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Geisinger Wyoming Valley Coordinator of this site? Confirm its status | Wilkes-Barre | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.