NCT05266872Recruiting
Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme
Biomaterial Collection for Neurodegenerative Disease Research (ND Collection)
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen post-mortem diagnostic validation (Hipp et al., 2018). The cohort consists of more than 1,600 participants from Luxembourg and the Greater Region, comprising patients with typical PD or atypical parkinsonism - irrespective of disease stage, age, cognitive status, comorbidities, or linguistic background - followed-up annually and age- and sex-matched healthy control subjects followed-up every 4 years. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, the investigators have implemented an open-source digital platform that has been partly harmonized with other international PD cohort studies. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies (including blood, urine, stool, saliva, hair, skin biopsy and cerebrospinal fluid). All data and samples are stored, curated, and integrated into state-of-the-art data and biobank facilities.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1800 (estimated)
- First submitted
- 17 Jun 2021
- Start date
- 19 Dec 2014
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Luxembourg Institute of Health
- Diseases
- Parkinson disease
- NCT number
- NCT05266872
What you commit to
- Study type: Observational
- Planned participants: 1800
- From 19 Dec 2014 to the primary completion date, 31 Dec 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active cancer
- For invasive procedures, i.e., lumbar puncture and skin biopsy: relevant blood clotting impairment, e.g., anamnestic evidence of frequent or prolonged bleedings.
Age
- Underage subjects of less than 18 years of age
Other
- Refusal to sign the informed consent
- Limited capacity of consent on the part of the donor, if there is no legally determined guardian/authorised representative, or the latter is not present or does not agree with the inclusion
- Pregnant women
- Refusal to comply with mandatory sample collection
Who the study is looking for
- Subjects with neurodegenerative disease or having Parkinson's disease (typical PD or atypical parkinsonism)
- Subjects of all genders with a full capacity of consent
- Subjects with a limited consent capacity if the legal guardian/authorised representative is in agreement
- Subjects of at least 18 years of age at the time of inclusion
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier de Luxembourg (CHL), "Parkinson's Research Clinic" Coordinator of this site? Confirm its status | Luxembourg | Luxembourg | Recruiting |
| Clinical and Epidemiological Investigation Center (CIEC) Coordinator of this site? Confirm its status | Luxembourg | Luxembourg | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.