NCT05266976Recruiting
Mode of Exercise and Bone Biomarkers in Older Veterans
Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 9 Feb 2022
- Start date
- 6 Jul 2022
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Osteoporosis
- NCT number
- NCT05266976
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 6 Jul 2022 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg;
- History of type 1 or type 2 diabetes
- Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist
Lab values
- Hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal
- Serum Ca \<8.5 or \>10.3 mg/dL
- Serum 25(OH)D \<20 ng/mL
- Anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men
- Current diagnosis or symptoms of COVID-19
- In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider. Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider.
Other
- Impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2
- Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L
- Fracture in the past 6 months
Who the study is looking for
- Healthy older (60+ y) Veteran women and men in the Denver Metro Area
- Normally active (e.g., recreational cycling or walking exercise)
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rocky Mountain Regional VA Medical Center, Aurora, CO Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.