NCT05268887Recruiting
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease
Acute Treatment of Parkinson's Disease With Gamma Frequency Stimulation
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab has developed a non-invasive method of increasing gamma power in the brain using Gamma Entrainment Using Sensory Stimulation (GENUS) through light, sound, and tactile stimulation devices. For this study, 40 participants with mild Parkinson's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light, sound, and tactile stimulation to determine the safety, feasibility, and optimization of GENUS as a potential therapy in the PD population.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 6 Jan 2022
- Start date
- 9 Feb 2022
- Primary completion date
- 1 Nov 2027
- Lead sponsor
- Massachusetts Institute of Technology
- Diseases
- Parkinson disease
- NCT number
- NCT05268887
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 9 Feb 2022 to the primary completion date, 1 Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- currently taking sedative medications that are clinically contraindicated
- has undergone recent change (\<1 month) in medication
- recent drug or alcohol abuse or dependence
Other illness
- Subject has atypical Parkinson's syndrome(s) due to drugs, metabolic neurogenetic disorders (e.g., Wilson's Disease), encephalitis, cerebrovascular disease, or degenerative disease (e.g., Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Lewy Body dementia)
- history of any psychiatric illness that would pose a safety risk
- diagnosis of dementia or other neurological conditions
- history of epilepsy, stroke, or seizure in past 24 months
Lab values
- laboratory results the would pose safety risk
Other
- concurrently or has participated in other clinical trial investigation within 3 months
- pregnant
- no healthcare
- diagnosis of migraines
- have certain implantable medical devices
- contraindications for MRI
- life expectancy of less than 2 years
Who the study is looking for
- Subject has Idiopathic PD defined by the cardinal sign, bradykinesia, plus the presence of at least 1 of the following: resting tremor or rigidity and without any other known or suspected cause of Parkinsonism (according to Movement disorder society (MDS) clinical diagnostic criteria for Parkinson's disease confirmed by a fellowship trained movements disorder specialist
- Subject is Hoehn \& Yahr stage 2 to 3
- Subject has a Montreal Cognitive Assessment (MOCA) score ≥26.
- Subject is \> 45 and \<90 years of age.
- proficient in speaking, reading, and understanding English
- capable of providing informed written consent
- Subject is on a stable dose (at least 1 month prior to baseline visit) of antiparkinsonian agents and willing to remain on this dose for the duration of the study. If on a cholinesterase inhibitor, a stable dose without changes for 1 month is required.
- Subject has undergone a brain CT or MRI prior to rule out underlying structural lesions
Age in the registry: 45 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts Institute of Technology Coordinator of this site? Confirm its status | Cambridge | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.