NCT05273164Completed
State Representation in Early Psychosis
Source: ClinicalTrials.gov · Last updated 22 Sept 2025
Brief summary (registry, in English)
The purpose of this study is to examine state representation in individuals aged 15-45 who have been diagnosed with a psychotic illness, as well as young adults who do not have a psychiatric diagnosis. State Representation is our ability to process information about our surroundings. Participants will complete computerized tasks that measure state representation while having their brain activity measured.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 277 (actual)
- First submitted
- 24 Jan 2022
- Start date
- 1 Dec 2021
- Primary completion date
- 29 Aug 2025
- Lead sponsor
- University of Minnesota
- Diseases
- Schizophrenia
- NCT number
- NCT05273164
What you commit to
- Study type: Observational
- Participants enrolled: 277
- From 1 Dec 2021 to the primary completion date, 29 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous clinically significant head injury or prolonged unconsciousness, as determined by the PI/Co-Is
- Previous intent to act on suicidal ideation with a specific plan and/or preparatory acts within 6 months of enrollment, as indicated by the C-SSRS
- Additional Exclusion Criteria for Control Participants:
Other illness
- Presence of a major neurological disorder (psychosis participants may have an autism spectrum diagnosis)
- The presence of any major medical condition that, in the opinion of the PI/Co-Is, would impede participation in the study or would put the participant at additional risk by participating
- Meets DSM-5 criteria for psychotic, bipolar, or autism spectrum disorder
- Has a family history (1st degree relative) of psychotic, bipolar, or autism spectrum disorder
Other
- Unable or unwilling to provide informed consent
- The participant is unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in the research study
- Participant is pregnant
- Participant is illiterate
- Cannot pass the CMRR Subject Safety Screen due to MRI contraindications
- Meets criteria for substance or alcohol dependence within 3 months of enrollment
- Presence of severe alcohol or substance abuse
- Has participated in significant formal cognitive training programs, as determined by the PI/Co-Is
- Additional Exclusion Criteria for Early Psychosis Participants:
- Meets criteria for clinical risk of suicidal behavior, as defined by:
- Clinician judgement
- A suicide attempt within 6 months of enrollment
- Active suicidal ideation at screening or baseline, as indicated by the C-SSRS
Who the study is looking for
- English proficiency, as determined by staff observation and participant self-report
- Estimated IQ at or above 70, as estimated by the cognitive assessments
- Additional Inclusion Criteria for Early Psychosis Participants:
- Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis; those aged 36-45 years old must have had with onset of psychotic symptoms within the previous 5 years
- Achieved clinical stability, defined as outpatient status for at least one month prior to study participation
Age in the registry: 15 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.