NCT05278065Completed
E-cigarettes for Harm Reduction in Adults With Asthma
Complimentary Electronic Cigarettes for Harm Reduction Among Adult Smokers With Asthma
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
Smoking is the main cause of preventable disease and death in the US and impacts respiratory illnesses including COPD and asthma. However, little is known about the effects on smoking and lung health of substituting cigarettes with ENDS in adults with asthma. This project aims to test whether providing ENDS to adults with asthma will lead to substitution of smoking for ENDS, reduced dependence, and improved lung function so such knowledge can inform interventions to reduce the public health burden of tobacco.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 17 (actual)
- First submitted
- 4 Feb 2022
- Start date
- 1 May 2022
- Primary completion date
- 12 Sept 2024
- Lead sponsor
- Brown University
- Diseases
- Asthma
- NCT number
- NCT05278065
What you commit to
- Study type: Interventional
- Participants enrolled: 17
- From 1 May 2022 to the primary completion date, 12 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Intention to quit smoking during the next 30 days;
- Current engagement in any smoking cessation treatment;
- Current self-identification as regular ENDS user or using ENDS \> 2 days / week;
- Medical contraindication to nicotine;
- Pregnancy (due to toxicity of nicotine and tobacco products);
- Current alcohol dependence (AUDIT \> 15)
- Urine-screened or past-month self-reported use of illicit substances (amphetamine, cocaine, methamphetamine, opioids, benzodiazepines);
- Current psychosis, mania, or suicidal ideation;
Who the study is looking for
- Male or female (50%), 21 to 65 (inclusive) years of age;
- Persistent asthma symptoms (i.e., episodic symptoms of airflow obstruction / airway hyperresponsiveness (AHR) as documented in review of medical history);
- Currently prescribed SABA medication;
- Past-year smoking of ≥5 cigarettes/day;
- Exhaled CO ≥ 6 ppm at baseline;
- Zero breath alcohol during informed consent for participation;
- English-speaking at an 8th grade level.
Age in the registry: 21 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Center for Alcohol and Addiction Studies Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.