NCT05284747Active, not recruitingPhase 4
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction
Source: ClinicalTrials.gov · Last updated 6 Oct 2025
Brief summary (registry, in English)
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction \[NSTEMI\] and ST-segment elevation myocardial infarction \[STEMI\]).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 6019 (actual)
- First submitted
- 9 Mar 2022
- Start date
- 26 Oct 2022
- Primary completion date
- 29 May 2027
- Lead sponsor
- Amgen
- Diseases
- Coronary artery disease, Stroke
- NCT number
- NCT05284747
- EudraCT number
- 2021-005272-19
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 6019
- From 26 Oct 2022 to the primary completion date, 29 May 2027
- 120 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants with elevated biomarkers of myocardial injury due to secondary/nonatherosclerotic etiology (eg, sepsis, atrial fibrillation, vasospasm, decompensated heart failure, uncontrolled hypertension, stress induced cardiomyopathy)
Other
- Participants requiring invasive hemodynamic and/or vasopressor/inotropic support at the time of screening
Who the study is looking for
- Age greater than or equal to 18 years
- Hospitalized for primary reason of NSTEMI or STEMI due to presumed atherosclerotic disease
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (120)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro de Pesquisa Clinica do Coracao Coordinator of this site? Confirm its status | Aracaju | Brazil | Unknown status |
| Hospital Madre Teresa Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Hospital Universitário Ciências Médicas de Belo Horizonte Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| Instituto de Pesquisa Clínica de Campinas Coordinator of this site? Confirm its status | Campinas | Brazil | Unknown status |
| Ps Cardiologico de PE - Procape Coordinator of this site? Confirm its status | Casa Forte | Brazil | Unknown status |
| Hospital Universitario Sao Francisco na Providencia de Deus Coordinator of this site? Confirm its status | Ipiranga Goiânia | Brazil | Unknown status |
| Hospital Ruy Azeredo Coordinator of this site? Confirm its status | Ipiranga Goiânia | Brazil | Unknown status |
| Cmep-Centro Multidisciplinar Ensino e Pesq Coordinator of this site? Confirm its status | Joinville | Brazil | Unknown status |
| Instituto Cardiovascular de Linhares Coordinator of this site? Confirm its status | Linhares | Brazil | Unknown status |
| Irmandade da Santa Casa de Misericordia de Marilia Coordinator of this site? Confirm its status | Marília | Brazil | Unknown status |
| Instituto Atena de Pesquisa Clínica Coordinator of this site? Confirm its status | Natal | Brazil | Unknown status |
| Hospital do Coracao de Pocos de Caldas CEC servicos medicos Coordinator of this site? Confirm its status | Poços de Caldas | Brazil | Unknown status |
| Hospital Mae de Deus Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Instituto de Cardiologia do Rio Grande do Sul Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Santa Casa de Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Hospital de Clinicas de Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Instituto de Cardiologia de Santa Catarina Coordinator of this site? Confirm its status | Praia Comprida, Sao Jose | Brazil | Unknown status |
| Hospital Regional de Presidente Prudente Coordinator of this site? Confirm its status | Presidente Prudente | Brazil | Unknown status |
| Clínica Silvestre Sante Coordinator of this site? Confirm its status | Rio Branco | Brazil | Unknown status |
| Instituto Dante Pazanesse Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Instituto do coracao da Faculdade de Medicina da Universidade de Sao Paulo - InCor Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Hospital Beneficencia Portuguesa Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Hospital Israelita Albert Einstein Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Alingsas Lasarett Coordinator of this site? Confirm its status | Alingsås | Sweden | Unknown status |
| Gävle sjukhus Coordinator of this site? Confirm its status | Gävle | Sweden | Unknown status |
| Lanssjukhuset Ryhov Coordinator of this site? Confirm its status | Jönköping | Sweden | Unknown status |
| Blekingesjukhuset Karlskrona Coordinator of this site? Confirm its status | Karlskrona | Sweden | Unknown status |
| Linkoping University Hospital Coordinator of this site? Confirm its status | Linköping | Sweden | Unknown status |
| Sunderby Sjukhus Coordinator of this site? Confirm its status | Luleå | Sweden | Unknown status |
| Skane Universitetssjukhus i Lund Coordinator of this site? Confirm its status | Lund | Sweden | Unknown status |
| Molndals Sjukhus Coordinator of this site? Confirm its status | Molndahl | Sweden | Unknown status |
| Vrinnevisjukhuset, Norrkoeping Coordinator of this site? Confirm its status | Norrköping | Sweden | Unknown status |
| Östersunds sjukhus Coordinator of this site? Confirm its status | Östersund | Sweden | Unknown status |
| Södersjukhuset Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
| Sundsvalls Sjukhus Coordinator of this site? Confirm its status | Sundsvall | Sweden | Unknown status |
| Akademiska Sjukhuset i Uppsala Coordinator of this site? Confirm its status | Uppsala | Sweden | Unknown status |
| Västmanlands Sjukhus Västerås Coordinator of this site? Confirm its status | Västerås | Sweden | Unknown status |
| Centrallasarettet Växjö Coordinator of this site? Confirm its status | Vaxjo | Sweden | Unknown status |
| University of Colorado Hospital Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Ascension Texas Cardiovascular Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| South Shore University Hospital Northwell Health Coordinator of this site? Confirm its status | Bay Shore | United States | Unknown status |
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Excel Medical Clinical Trials Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| Saint Lukes Boise Medical Center Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Bridgeport Hospital Coordinator of this site? Confirm its status | Bridgeport | United States | Unknown status |
| Advanced Heart Care LLC Coordinator of this site? Confirm its status | Bridgewater | United States | Unknown status |
| Aultman Hospital Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Wellspan Chambersburg Hospital Coordinator of this site? Confirm its status | Chambersburg | United States | Unknown status |
| University of North Carolina Cardiology Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Novant Health Heart and Vascular Institute Presbyterian Medical Center Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Jesse Brown Veterans Affairs Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Great Lakes Clinical Trials - Ravenswood Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Clearwater Cardiovascular Consultants Coordinator of this site? Confirm its status | Clearwater | United States | Unknown status |
| Prisma Upstate and Midlands Greenville Hospital System Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| The Ohio State University -Wexner Medical Center Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| John Muir Health and Cardiovascular Institute Coordinator of this site? Confirm its status | Concord | United States | Unknown status |
| Henry Ford Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Essentia Health Saint Marys Medical Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Eastern Shore Research Institute Coordinator of this site? Confirm its status | Fairhope | United States | Unknown status |
| Northern Arizona Healthcare Corporation Cardiovascular Institute Coordinator of this site? Confirm its status | Flagstaff | United States | Unknown status |
| University of Florida at Gainesville Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Healthy Heart Cardiology Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Moses H Cone Memorial Hospital Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Upstate Cardiology Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Hackensack University Medical Center Coordinator of this site? Confirm its status | Hackensack | United States | Unknown status |
| Hartford Hospital Coordinator of this site? Confirm its status | Hartford | United States | Unknown status |
| Heart Center Research, LLC Coordinator of this site? Confirm its status | Huntsville | United States | Unknown status |
| Ascension Saint Vincent Heart Center Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Jackson Heart Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| University of Florida and Shands Hospital Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| University of Kansas Hospital Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Saint Lukes Hospital of Kansas City Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Tennova Healthcare-Turkey Creek Medical Center Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Ascension Texas Cardiovascular Kyle Coordinator of this site? Confirm its status | Kyle | United States | Unknown status |
| Lancaster General Hospital/The Heart Group of Lancaster Coordinator of this site? Confirm its status | Lancaster | United States | Unknown status |
| Sparrow Clinical Research Institute Coordinator of this site? Confirm its status | Lansing | United States | Unknown status |
| VA Greater Los Angeles Healthcare System Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of California, Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Louisville Health / Jewish Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Bon Secours St Marys Hospital Richmond Coordinator of this site? Confirm its status | Midlothian | United States | Unknown status |
| Aurora Saint Lukes Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| McLaren Macomb Research Services Coordinator of this site? Confirm its status | Mount Clemens | United States | Unknown status |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Ascension Saint Thomas Nashville Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Saint Michaels Medical Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| New York - Presbyterian - Weill Cornell Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| North Kansas City Hospital Coordinator of this site? Confirm its status | North Kansas City | United States | Unknown status |
| Parkway Cardiology Associates Coordinator of this site? Confirm its status | Oak Ridge | United States | Unknown status |
| University of California Irvine Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| AdventHealth Orlando Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Midwest Heart and Vascular Specialists Coordinator of this site? Confirm its status | Overland Park | United States | Unknown status |
| Cardiology Partners Clinical Research Institute Coordinator of this site? Confirm its status | Palm Beach Gardens | United States | Unknown status |
| Advocate Lutheran General Hospital Coordinator of this site? Confirm its status | Park Ridge | United States | Unknown status |
| Baptist Health Care Coordinator of this site? Confirm its status | Pensacola | United States | Unknown status |
| Ascension Sacred Heart Coordinator of this site? Confirm its status | Pensacola | United States | Unknown status |
| McLaren Northern Michigan Hospital Coordinator of this site? Confirm its status | Petoskey | United States | Unknown status |
| Hudson Valley Cardiovascular Practice PC Coordinator of this site? Confirm its status | Poughkeepsie | United States | Unknown status |
| Cardiovascular Research of Knoxville North Knoxville Medical Center Coordinator of this site? Confirm its status | Powell | United States | Unknown status |
| Rhode Island Hospital Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
| Chippenham Hospital Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Reid Physician Associates Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| University of Rochester Medical Center Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Advanced Cardiology Associates Coordinator of this site? Confirm its status | Rochester Hills | United States | Unknown status |
| Clearwater Cardiovascular Consultants Coordinator of this site? Confirm its status | Safety Harbor | United States | Unknown status |
| Scottsdale Healthcare at Shea - HonorHealth Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| Cardiology Associates of Fairfield County PC Coordinator of this site? Confirm its status | Stamford | United States | Unknown status |
| Richmond University Medical Center Coordinator of this site? Confirm its status | Staten Island | United States | Unknown status |
| Stony Brook Medicine Coordinator of this site? Confirm its status | Stony Brook | United States | Unknown status |
| Tampa Cardiovascular Interventions and Research Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Montefiore Medical Center Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Pima Heart and Vascular Clinical Research Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Ascension Saint John Bartlesville Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Ascension Saint John Tulsa Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Cardiology Associates of North Mississippi Coordinator of this site? Confirm its status | Tupelo | United States | Unknown status |
| Kent Hospital Coordinator of this site? Confirm its status | Warwick | United States | Unknown status |
| Reading Hospital Tower Health Coordinator of this site? Confirm its status | West Reading | United States | Unknown status |
| Clinical Site Partners Orlando dba Flourish Research Coordinator of this site? Confirm its status | Winter Park | United States | Unknown status |
| Genesis HealthCare System Coordinator of this site? Confirm its status | Zanesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.