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NCT05284747Active, not recruitingPhase 4

EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction

Source: ClinicalTrials.gov · Last updated 6 Oct 2025

Brief summary (registry, in English)

The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction \[NSTEMI\] and ST-segment elevation myocardial infarction \[STEMI\]).

Status (registry)
Active, not recruiting
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
6019 (actual)
First submitted
9 Mar 2022
Start date
26 Oct 2022
Primary completion date
29 May 2027
Lead sponsor
Amgen
NCT number
NCT05284747
EudraCT number
2021-005272-19

What you commit to

  • Study type: Interventional · Phase 4
  • Participants enrolled: 6019
  • From 26 Oct 2022 to the primary completion date, 29 May 2027
  • 120 sites in 3 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Participants with elevated biomarkers of myocardial injury due to secondary/nonatherosclerotic etiology (eg, sepsis, atrial fibrillation, vasospasm, decompensated heart failure, uncontrolled hypertension, stress induced cardiomyopathy)

Other

  • Participants requiring invasive hemodynamic and/or vasopressor/inotropic support at the time of screening

Who the study is looking for

  • Age greater than or equal to 18 years
  • Hospitalized for primary reason of NSTEMI or STEMI due to presumed atherosclerotic disease

Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (120)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Centro de Pesquisa Clinica do Coracao
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AracajuBrazilUnknown status
Hospital Madre Teresa
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Belo HorizonteBrazilUnknown status
Hospital Universitário Ciências Médicas de Belo Horizonte
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Belo HorizonteBrazilUnknown status
Instituto de Pesquisa Clínica de Campinas
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CampinasBrazilUnknown status
Ps Cardiologico de PE - Procape
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Casa ForteBrazilUnknown status
Hospital Universitario Sao Francisco na Providencia de Deus
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Ipiranga GoiâniaBrazilUnknown status
Hospital Ruy Azeredo
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Ipiranga GoiâniaBrazilUnknown status
Cmep-Centro Multidisciplinar Ensino e Pesq
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JoinvilleBrazilUnknown status
Instituto Cardiovascular de Linhares
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LinharesBrazilUnknown status
Irmandade da Santa Casa de Misericordia de Marilia
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MaríliaBrazilUnknown status
Instituto Atena de Pesquisa Clínica
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NatalBrazilUnknown status
Hospital do Coracao de Pocos de Caldas CEC servicos medicos
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Poços de CaldasBrazilUnknown status
Hospital Mae de Deus
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Porto AlegreBrazilUnknown status
Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento
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Porto AlegreBrazilUnknown status
Instituto de Cardiologia do Rio Grande do Sul
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Porto AlegreBrazilUnknown status
Santa Casa de Porto Alegre
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Porto AlegreBrazilUnknown status
Hospital de Clinicas de Porto Alegre
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Porto AlegreBrazilUnknown status
Instituto de Cardiologia de Santa Catarina
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Praia Comprida, Sao JoseBrazilUnknown status
Hospital Regional de Presidente Prudente
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Presidente PrudenteBrazilUnknown status
Clínica Silvestre Sante
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Rio BrancoBrazilUnknown status
Instituto Dante Pazanesse
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São PauloBrazilUnknown status
Instituto do coracao da Faculdade de Medicina da Universidade de Sao Paulo - InCor
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São PauloBrazilUnknown status
Hospital Beneficencia Portuguesa
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São PauloBrazilUnknown status
Hospital Israelita Albert Einstein
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São PauloBrazilUnknown status
Alingsas Lasarett
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AlingsåsSwedenUnknown status
Gävle sjukhus
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GävleSwedenUnknown status
Lanssjukhuset Ryhov
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JönköpingSwedenUnknown status
Blekingesjukhuset Karlskrona
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KarlskronaSwedenUnknown status
Linkoping University Hospital
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LinköpingSwedenUnknown status
Sunderby Sjukhus
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LuleåSwedenUnknown status
Skane Universitetssjukhus i Lund
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LundSwedenUnknown status
Molndals Sjukhus
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MolndahlSwedenUnknown status
Vrinnevisjukhuset, Norrkoeping
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NorrköpingSwedenUnknown status
Östersunds sjukhus
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ÖstersundSwedenUnknown status
Södersjukhuset
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StockholmSwedenUnknown status
Sundsvalls Sjukhus
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SundsvallSwedenUnknown status
Akademiska Sjukhuset i Uppsala
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UppsalaSwedenUnknown status
Västmanlands Sjukhus Västerås
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VästeråsSwedenUnknown status
Centrallasarettet Växjö
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VaxjoSwedenUnknown status
University of Colorado Hospital
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AuroraUnited StatesUnknown status
Ascension Texas Cardiovascular
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AustinUnited StatesUnknown status
South Shore University Hospital Northwell Health
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Bay ShoreUnited StatesUnknown status
University of Alabama at Birmingham
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BirminghamUnited StatesUnknown status
Excel Medical Clinical Trials
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Boca RatonUnited StatesUnknown status
Saint Lukes Boise Medical Center
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BoiseUnited StatesUnknown status
Massachusetts General Hospital
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BostonUnited StatesUnknown status
Bridgeport Hospital
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BridgeportUnited StatesUnknown status
Advanced Heart Care LLC
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BridgewaterUnited StatesUnknown status
Aultman Hospital
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CantonUnited StatesUnknown status
Wellspan Chambersburg Hospital
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ChambersburgUnited StatesUnknown status
University of North Carolina Cardiology
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Chapel HillUnited StatesUnknown status
Novant Health Heart and Vascular Institute Presbyterian Medical Center
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CharlotteUnited StatesUnknown status
Jesse Brown Veterans Affairs Medical Center
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ChicagoUnited StatesUnknown status
Great Lakes Clinical Trials - Ravenswood
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ChicagoUnited StatesUnknown status
Clearwater Cardiovascular Consultants
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ClearwaterUnited StatesUnknown status
Prisma Upstate and Midlands Greenville Hospital System
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ColumbiaUnited StatesUnknown status
The Ohio State University -Wexner Medical Center
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ColumbusUnited StatesUnknown status
John Muir Health and Cardiovascular Institute
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ConcordUnited StatesUnknown status
Henry Ford Hospital
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DetroitUnited StatesUnknown status
Essentia Health Saint Marys Medical Center
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DuluthUnited StatesUnknown status
Eastern Shore Research Institute
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FairhopeUnited StatesUnknown status
Northern Arizona Healthcare Corporation Cardiovascular Institute
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FlagstaffUnited StatesUnknown status
University of Florida at Gainesville
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GainesvilleUnited StatesUnknown status
Healthy Heart Cardiology
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Grand RapidsUnited StatesUnknown status
Moses H Cone Memorial Hospital
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GreensboroUnited StatesUnknown status
Upstate Cardiology
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GreenvilleUnited StatesUnknown status
Hackensack University Medical Center
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HackensackUnited StatesUnknown status
Hartford Hospital
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HartfordUnited StatesUnknown status
Heart Center Research, LLC
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HuntsvilleUnited StatesUnknown status
Ascension Saint Vincent Heart Center
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IndianapolisUnited StatesUnknown status
Jackson Heart
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JacksonUnited StatesUnknown status
University of Florida and Shands Hospital
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JacksonvilleUnited StatesUnknown status
University of Kansas Hospital
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Kansas CityUnited StatesUnknown status
Saint Lukes Hospital of Kansas City
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Kansas CityUnited StatesUnknown status
Tennova Healthcare-Turkey Creek Medical Center
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KnoxvilleUnited StatesUnknown status
Ascension Texas Cardiovascular Kyle
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KyleUnited StatesUnknown status
Lancaster General Hospital/The Heart Group of Lancaster
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LancasterUnited StatesUnknown status
Sparrow Clinical Research Institute
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LansingUnited StatesUnknown status
VA Greater Los Angeles Healthcare System
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Los AngelesUnited StatesUnknown status
University of California, Los Angeles
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Los AngelesUnited StatesUnknown status
University of Louisville Health / Jewish Hospital
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LouisvilleUnited StatesUnknown status
Bon Secours St Marys Hospital Richmond
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MidlothianUnited StatesUnknown status
Aurora Saint Lukes Medical Center
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MilwaukeeUnited StatesUnknown status
McLaren Macomb Research Services
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Mount ClemensUnited StatesUnknown status
Vanderbilt University Medical Center
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NashvilleUnited StatesUnknown status
Ascension Saint Thomas Nashville
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NashvilleUnited StatesUnknown status
Saint Michaels Medical Center
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NewarkUnited StatesUnknown status
New York - Presbyterian - Weill Cornell Medical Center
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New YorkUnited StatesUnknown status
North Kansas City Hospital
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North Kansas CityUnited StatesUnknown status
Parkway Cardiology Associates
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Oak RidgeUnited StatesUnknown status
University of California Irvine
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OrangeUnited StatesUnknown status
AdventHealth Orlando
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OrlandoUnited StatesUnknown status
Midwest Heart and Vascular Specialists
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Overland ParkUnited StatesUnknown status
Cardiology Partners Clinical Research Institute
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Palm Beach GardensUnited StatesUnknown status
Advocate Lutheran General Hospital
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Park RidgeUnited StatesUnknown status
Baptist Health Care
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PensacolaUnited StatesUnknown status
Ascension Sacred Heart
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PensacolaUnited StatesUnknown status
McLaren Northern Michigan Hospital
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PetoskeyUnited StatesUnknown status
Hudson Valley Cardiovascular Practice PC
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PoughkeepsieUnited StatesUnknown status
Cardiovascular Research of Knoxville North Knoxville Medical Center
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PowellUnited StatesUnknown status
Rhode Island Hospital
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ProvidenceUnited StatesUnknown status
Chippenham Hospital
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RichmondUnited StatesUnknown status
Reid Physician Associates
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RichmondUnited StatesUnknown status
University of Rochester Medical Center
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RochesterUnited StatesUnknown status
Advanced Cardiology Associates
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Rochester HillsUnited StatesUnknown status
Clearwater Cardiovascular Consultants
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Safety HarborUnited StatesUnknown status
Scottsdale Healthcare at Shea - HonorHealth
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ScottsdaleUnited StatesUnknown status
Cardiology Associates of Fairfield County PC
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StamfordUnited StatesUnknown status
Richmond University Medical Center
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Staten IslandUnited StatesUnknown status
Stony Brook Medicine
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Stony BrookUnited StatesUnknown status
Tampa Cardiovascular Interventions and Research
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TampaUnited StatesUnknown status
Montefiore Medical Center
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The BronxUnited StatesUnknown status
Pima Heart and Vascular Clinical Research
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TucsonUnited StatesUnknown status
Ascension Saint John Bartlesville
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TulsaUnited StatesUnknown status
Ascension Saint John Tulsa
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TulsaUnited StatesUnknown status
Cardiology Associates of North Mississippi
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TupeloUnited StatesUnknown status
Kent Hospital
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WarwickUnited StatesUnknown status
Reading Hospital Tower Health
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West ReadingUnited StatesUnknown status
Clinical Site Partners Orlando dba Flourish Research
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Winter ParkUnited StatesUnknown status
Genesis HealthCare System
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ZanesvilleUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.