NCT05285631Completed
Early Prediction of ICD Candidacy After Anterior Myocardial Infarction
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
Despite the advances of pharmacologic and interventional therapies, sudden (or arrhythmic) cardiac death remains very high in the early weeks-to-months after an acute myocardial infarction (MI).The majority of cardiac arrests occur in patients who have large infarctions resulting in extensive myocardial damage, which is translated into lower left ventricular ejection fraction (LVEF). Hence, low LVEF remains -to the current time- the most robust predictor for post MI sudden (and presumably arrhythmic) death; and is the determinant for implantable cardioverter defibrillator (ICD) candidacy for primary prevention as per clinical practice guidelines.ICD significantly and effectively reduced ventricular arrhythmia (VA)-mediated cardiac deaths among these patients.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 200 (actual)
- First submitted
- 11 Feb 2022
- Start date
- 31 May 2022
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Aswan University
- Diseases
- Coronary artery disease
- NCT number
- NCT05285631
What you commit to
- Study type: Observational
- Participants enrolled: 200
- From 31 May 2022 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- ● Refusal to participate in the study.
- Patients with existing ICD or pacemakers.
- Qualifying ICD for secondary prevention.
- Known to have LVEF ≤ 40% prior to the index MI.
- Previous PCI to Left anterior Descending artery (LAD).
- Previous or being scheduled for CABG within ≤ 3 months.
- Known to have limited life expectancy (less than 1-year) prior to the index MI.
- Pregnant or lactating women.
Who the study is looking for
- Age between 18 and 80 years. Both genders are eligible.
- Patients with diagnosis of an acute anterior STEMI and revascularized with successful primary percutaneous coronary intervention (PCI) within 24 hours.
- LVEF \< 40 % assessed by Bi-plane Simpsons rule within 48 hour post PCI.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Magdi Yacoub Foundation Coordinator of this site? Confirm its status | Aswān | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.