NCT05307809Recruiting
Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
Cytokine Expression in Sera, ex Vivo Stimulated Peripheral Blood Mononuclear Cells Culture, and Skin in Psoriasis - Comparison of Patients With and Without Joint Involvement
Source: ClinicalTrials.gov · Last updated 31 Aug 2026
Brief summary (registry, in English)
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 23 Mar 2022
- Start date
- 17 Aug 2022
- Primary completion date
- 17 Feb 2027
- Lead sponsor
- Poitiers University Hospital
- Diseases
- Psoriasis, Psoriatic arthritis
- NCT number
- NCT05307809
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 17 Aug 2022 to the primary completion date, 17 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Other
- ▪ For psoriasis patients :
- Joint damage according to CASPAR criteria
- Echography activity in favor of chronic inflammatory rheumatism
- For patients and controls:
- Without social protection rights
Who the study is looking for
- For psoriasis patients :
- Age over 18 years old
- Signed informed consent
- 5 year old psoriasis at least
- At least one skin lesion over 2 cm
- Without any articular symptoms
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With normal articular and enthesis sonography
- For psoriatic arthritis patients :
- Age over 18 years old
- Signed informed consent
- Psoriatic arthritis according to CASPAR criteria
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With at least one synovitis at inclusion
- For controls
- Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
- No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old
Age in the registry: 18 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.