NCT05307965Completed
RETRIEVE-AMI Study
Stent Retriever Thrombectomy for Thrombus Burden Reduction in Patients With Acute Myocardial Infarction - RETRIEVE-AMI Study
Source: ClinicalTrials.gov · Last updated 5 Sept 2025
Brief summary (registry, in English)
Heart attacks are caused by the sudden formation of a clot inside a diseased coronary artery which reduces blood flow beyond the blockage site. During conventional treatment of the blockage with what is known as a stent; a stainless steel tub that keeps the artery open, the clot that has formed is disrupted and is pushed further down leading to damage in smaller blood vessels supplying the heart muscle. This additional damage can lead to long-term heart muscle damage influencing recovery and wellbeing. The original concept that was tested to prevent this 'clot shower' was that of a suction device to withdraw the clot before stenting. However, this approach has not translated to patient benefit. Amongst the reasons put forward for the inefficacy of the suction device was that it does not remove the entire clot as it does not interact with it. A new device that physically interacts with the clot and traps it before pulling it out - the stent retriever - is now routinely used in stroke therapy to remove clots in the arteries supplying the brain. This device has been successfully used as a last resort to remove clots in a small number of heart attacks. The investigators hypothesize that stent retriever therapy will be more effective in clot removal than the current standard of care; suction or stenting. To study this, the investigators propose the RETRIEVE-AMI randomised controlled trial.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 81 (actual)
- First submitted
- 2 Mar 2022
- Start date
- 6 May 2022
- Primary completion date
- 24 Oct 2024
- Lead sponsor
- Oxford University Hospitals NHS Trust
- Diseases
- Coronary artery disease
- NCT number
- NCT05307965
What you commit to
- Study type: Interventional
- Participants enrolled: 81
- From 6 May 2022 to the primary completion date, 24 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous stent implanted proximal to the occlusion site
- Previous coronary artery bypass graft surgery (CABG)
- Previous STEMI/Transient Ischemic Attack/Stroke
Other illness
- Participant with known hypersensitivity to nickel-titanium
- Class Killip III/IV and/or profound bradycardia (Heart rate \< 40 bpm)
- Known history of kidney failure
- Stent thrombosis
Lab values
- Known anaemia (Hemoglobin \<9)
Other
- Female participant who is pregnant or lactating
- Unconscious at presentation
- Late presenter (pain to wire time \> 12 h)
- Ostial occlusion
- Highly tortuous vessel
- Highly calcified vessel
- Suspected (angiographically) spontaneous coronary artery dissection
Who the study is looking for
- Primary PCI patient with ST elevation myocardial infarction (STEMI)
- TIMI 0/1 flow at presentation
- Angiographic thrombus score ≥ 4
- Vessel diameter at site of occlusion ≥ 3.0 mm (measured by quantitative coronary angiography)
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oxford Heart Centre Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.