NCT05321927Completed
TENS in Persons With MS
Transcutaneous Electrical Nerve Stimulation in Persons With MS
Source: ClinicalTrials.gov · Last updated 10 Apr 2025
Brief summary (registry, in English)
Persons with multiple sclerosis (pwMS) often have an increased sense of fatigue. Furthermore, they present walking difficulties which negatively affects their mobility and results in an additional increase of fatigue. Previous literature suggests that transcutaneous electrical nerve stimulation (TENS) of leg muscles might increase their walking capacity and decrease perception of fatigue. In the present study we aim to investigate whether TENS of leg muscles reduces walking difficulties and sense of fatigue in pwMS in comparison with a short strength training protocol or no training. A similar aim is addressed after TENS of elbow flexor muscles. Subjects with relapsing remitting or progressive MS, will undergo transcutaneous electrical nerve stimulation (TENS), strength exercises (SExerc), both TENS and SExerc (COMB) simultaneously, or sham stimulation without training (CON) of both leg and arm muscles. Force and fatigue measurements are performed before, directly after and three weeks after the training sessions and contain walking, fatigue, and strength assessments. Main study parameters are changes in the scores of i) the six-minute walking test (6-MWT), ii) the perceived walking disability (MSWS-12) and iii) fatigue questionnaires (FSS and MFIS). Additional study parameters are changes in muscle force and muscle fatigability.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 80 (actual)
- First submitted
- 1 Apr 2022
- Start date
- 5 Jan 2023
- Primary completion date
- 15 Mar 2024
- Lead sponsor
- University Medical Center Groningen
- Diseases
- Multiple sclerosis
- NCT number
- NCT05321927
What you commit to
- Study type: Interventional
- Participants enrolled: 80
- From 5 Jan 2023 to the primary completion date, 15 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- planned a change in medication during the training period
Other illness
- having a psychiatric disorder
- having a neurological disorder other than MS
- having cardiovascular disorders and no positive advice from a sport medical examination
Other
- being a participant in an exercise study
- having cognitive or communication problems which reduces the capacity to understand instructions
- having a pacemaker or another implantable electronic apparatus.
- being pregnant
Who the study is looking for
- EDSS score \< 7
- MSWS score \> 30
- FSS score \> 4 or MFIS score \> 38.
- no known cardiovascular disorder or having a positive advice on a sport medical examination
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Medical Centre Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Unknown status |
Related publications
- Transcutaneous electrical nerve stimulation improves walking in fatigued persons with multiple sclerosis: a randomized controlled trial.Ann Phys Rehabil Med · 2026 · PMID 41679238
This page is information, not medical advice. Discuss any trial with your doctor.