A Clinical Study of the Paradise™ Renal Denervation System in Patients With Hypertension (RADIANCE-HTN DUO)

Prior treatment

• Any history of cerebrovascular event or severe cardiovascular event, within 6 months prior to consent
• Repeated hospitalization for hypertensive crisis (twice or more) within 12 months prior to obtaining consent, or any hospitalization for hypertensive crisis within 3 months prior to obtaining consent
• Patients who are taking drugs known to affect blood pressure and the investigator judges that it is not possible to discontinue these drugs during the study period

Other illness

• Secondary hypertension other than sleep apnea
• Type 1 diabetes mellitus or uncontrolled Type 2 diabetes
• Patients prescribed to drugs that have antihypertensive effects for other chronic diseases, and the investigator considers that discontinuation of these drugs may pose a serious risk to health
• Patients with a history of persistent or permanent atrial tachyarrhythmia
• Primary pulmonary hypertension
• Patients with contraindications or unacceptable anaphylactic reactions or uncontrolled allergy to contrast media

Lab values

• Patients with any of the following central laboratory tests at screening
  • Plasma aldosterone/renin ratio greater than or equal to 200 and plasma aldosterone greater than or equal to 60 pg/ml
  • HbA1c greater than or equal to 8.0%
  • eGFR less than 40 mL/min/1.73m2

Other

• Lacks appropriate renal artery anatomy for renal denervation
• Patients with active implantable medical devices
• Night shift workers
• Pregnant, nursing or planning to become pregnant

• Patients who have received antihypertensive treatment with two antihypertensive drugs (ARB/ACE inhibitor and Ca channel antagonist, either as a single agent or as a combination) for at least 4 weeks prior to obtaining consent, with no change in the type or dosage.
• Patients with a mean seated office blood pressure of between 140 mmHg and 180 mmHg systolic and between 90 mmHg and 110 mmHg diastolic at screening visit.
• Patients with a mean 24-hour ABPM (ambulatory blood pressure measurement) of between 130 mmHg and 170 mmHg systolic and between 80 mmHg and 105 mmHg diastolic at baseline visit