NCT05326399Recruiting
Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment: a Single-center, Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 369 (estimated)
- First submitted
- 26 Mar 2022
- Start date
- 1 Jun 2022
- Primary completion date
- 31 May 2027
- Lead sponsor
- RenJi Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT05326399
What you commit to
- Study type: Observational
- Planned participants: 369
- From 1 Jun 2022 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients received renal transplantation
Other illness
- hepatic failure
- uncontrolled mental disease or unable to cooperate during operation
Lab values
- severe bleeding risk or platelet \<70\*109/L
- chronic kidney insufficiency with eGFR\<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
Other
- Pregnancy or lactation
- not suitable for this study judged by investigaters
Who the study is looking for
- age 18-75 years
- patients received liver transplantation
- new onset of proteinuria(defined as 24-hour proteinuria\>1g/24h, or Urinary albumin creatinine ratio(UACR)\>300mg/g on at least two occasions), and/or renal impairment: eGFR \<60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
- have received renal biopsy in the past 3 months
- Signed informed consent form(ICF)
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.